Literature DB >> 10339658

Temporal and spatial expressions of transforming growth factor-betas and their receptors in epiphyseal growth plate.

S Matsunaga1, T Yamamoto, K Fukumura.   

Abstract

The activities of TGF-beta and its receptors in enchondral ossification have not yet been fully elucidated. The temporal and spatial expressions of TGF-beta and its receptors were examined immunohistochemically in epiphyseal growth plate of rats, in order to clarify the roles of TGF-beta and receptors in cartilage cells during enchondral ossification. TGF-beta1 and TGF-beta3 were expressed from 6 to 24 weeks in resting, proliferating, and maturing zone. TGF-beta2 was expressed at 6 week, but decreased during growth. The expression of TGF-betas in hypertrophic chondrocytes was weak. TbetaR-I was co-expressed with the ligand in resting, proliferating, and maturing zone throughout the development. The expressions of TbetaR-II was recognized at 6 weeks but decreased after that. This study suggests that TGF-betas play a major role in modulating endochondral ossification during growth in epiphyseal growth plate.

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Year:  1999        PMID： 10339658     DOI： 10.3892/ijo.14.6.1063

Source DB:  PubMed          Journal:  Int J Oncol        ISSN： 1019-6439            Impact factor:   5.650


  13 in total

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Review 5.  TGF-beta signaling in chondrocytes.

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Journal:  Front Biosci       Date:  2005-01-01

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Journal:  Mol Cell Biol       Date:  2002-09       Impact factor: 4.272

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10.  The effects of 1α, 25-dihydroxyvitamin D3 and transforming growth factor-β3 on bone development in an ex vivo organotypic culture system of embryonic chick femora.

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Journal:  PLoS One       Date:  2015-04-02       Impact factor: 3.240
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