Literature DB >> 10338535

Macrophages and epithelial cells respond differently to the Pseudomonas aeruginosa type III secretion system.

J Coburn1, D W Frank.   

Abstract

The multiple effects of Pseudomonas aeruginosa type III secretion have largely been attributed to variations in cytotoxin expression between strains. Here we show that the target cell type is also important. While lung epithelial cells showed significant changes in morphology but not viability when infected with P. aeruginosa, macrophages were efficiently killed by P. aeruginosa. Both responses were dependent on the type III secretion system.

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Year:  1999        PMID： 10338535      PMCID： PMC96636          DOI： 10.1128/IAI.67.6.3151-3154.1999

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  20 in total

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Authors:  C J Hueck
Journal:  Microbiol Mol Biol Rev       Date:  1998-06       Impact factor: 11.056

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Authors:  S Liu; T L Yahr; D W Frank; J T Barbieri
Journal:  J Bacteriol       Date:  1997-03       Impact factor: 3.490

3.  ExoU expression by Pseudomonas aeruginosa correlates with acute cytotoxicity and epithelial injury.

Authors:  V Finck-Barbançon; J Goranson; L Zhu; T Sawa; J P Wiener-Kronish; S M Fleiszig; C Wu; L Mende-Mueller; D W Frank
Journal:  Mol Microbiol       Date:  1997-08       Impact factor: 3.501

4.  Modification of Ras in eukaryotic cells by Pseudomonas aeruginosa exoenzyme S.

Authors:  E M McGuffie; D W Frank; T S Vincent; J C Olson
Journal:  Infect Immun       Date:  1998-06       Impact factor: 3.441

5.  Intracellular expression of the ADP-ribosyltransferase domain of Pseudomonas exoenzyme S is cytotoxic to eukaryotic cells.

Authors:  K J Pederson; J T Barbieri
Journal:  Mol Microbiol       Date:  1998-11       Impact factor: 3.501

6.  PepA, a secreted protein of Pseudomonas aeruginosa, is necessary for cytotoxicity and virulence.

Authors:  A R Hauser; P J Kang; J N Engel
Journal:  Mol Microbiol       Date:  1998-02       Impact factor: 3.501

7.  Pseudomonas aeruginosa-mediated cytotoxicity and invasion correlate with distinct genotypes at the loci encoding exoenzyme S.

Authors:  S M Fleiszig; J P Wiener-Kronish; H Miyazaki; V Vallas; K E Mostov; D Kanada; T Sawa; T S Yen; D W Frank
Journal:  Infect Immun       Date:  1997-02       Impact factor: 3.441

Review 8.  The exoenzyme S regulon of Pseudomonas aeruginosa.

Authors:  D W Frank
Journal:  Mol Microbiol       Date:  1997-11       Impact factor: 3.501

9.  ExoY, an adenylate cyclase secreted by the Pseudomonas aeruginosa type III system.

Authors:  T L Yahr; A J Vallis; M K Hancock; J T Barbieri; D W Frank
Journal:  Proc Natl Acad Sci U S A       Date:  1998-11-10       Impact factor: 11.205

10.  Regulation of ExoS production and secretion by Pseudomonas aeruginosa in response to tissue culture conditions.

Authors:  A J Vallis; T L Yahr; J T Barbieri; D W Frank
Journal:  Infect Immun       Date:  1999-02       Impact factor: 3.441
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  28 in total

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Journal:  Infect Immun       Date:  2005-01       Impact factor: 3.441

4.  Multiple domains are required for the toxic activity of Pseudomonas aeruginosa ExoU.

Authors:  V Finck-Barbançon; D W Frank
Journal:  J Bacteriol       Date:  2001-07       Impact factor: 3.490

Review 5.  Understanding host-pathogen interaction.

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Journal:  Infect Immun       Date:  2005-08       Impact factor: 3.441

7.  Cell death of human polymorphonuclear neutrophils induced by a Pseudomonas aeruginosa cystic fibrosis isolate requires a functional type III secretion system.

Authors:  D Dacheux; I Attree; C Schneider; B Toussaint
Journal:  Infect Immun       Date:  1999-11       Impact factor: 3.441

8.  Pseudomonas aeruginosa induces localized immunosuppression during pneumonia.

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9.  Characterization of Pseudomonas aeruginosa exoenzyme S as a bifunctional enzyme in J774A.1 macrophages.

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10.  The V antigen of Pseudomonas aeruginosa is required for assembly of the functional PopB/PopD translocation pore in host cell membranes.

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