Literature DB >> 1033700

The anesthetic potency of lidocaine in the rat.

C A DiFazio, J R Neiderlehner, R G Burney.   

Abstract

The anesthetic effect of lidocaine was evaluated in rats by determining the change in anesthetic requirement of cyclopropane MAC that was produced by blood concentrations of lidocaine in the clinically useful range. A linear reduction in anesthetic requirement was produced with concentrations up to 1 mug/ml. Further increases in lidocaine up to 5.5 mug/ml resulted in no further decrease in cyclopropane requirement. Lidocaine was found to contribute a maximum MAC fraction of 0.4.

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Year:  1976        PMID： 1033700     DOI： 10.1213/00000539-197611000-00016

Source DB:  PubMed          Journal:  Anesth Analg        ISSN： 0003-2999            Impact factor:   5.108


  7 in total

1.  Bidirectional modulation of isoflurane potency by intrathecal tetrodotoxin and veratridine in rats.

Authors:  Y Zhang; M Guzinski; E I Eger; M J Laster; M Sharma; R A Harris; H C Hemmings
Journal:  Br J Pharmacol       Date:  2010-01-25       Impact factor: 8.739

2.  TASK Channel Deletion Reduces Sensitivity to Local Anesthetic-induced Seizures.

Authors:  Guizhi Du; Xiangdong Chen; Marko S Todorovic; Shaofang Shu; Jaideep Kapur; Douglas A Bayliss
Journal:  Anesthesiology       Date:  2011-11       Impact factor: 7.892

3.  The thermodynamics of general and local anesthesia.

Authors:  Kaare Graesbøll; Henrike Sasse-Middelhoff; Thomas Heimburg
Journal:  Biophys J       Date:  2014-05-20       Impact factor: 4.033

4.  Risk appraisal of narcotic sedation for children.

Authors:  P A Moore; J M Goodson
Journal:  Anesth Prog       Date:  1985 Jul-Aug

5.  Protein kinase C co-expression and the effects of halothane on rat skeletal muscle sodium channels.

Authors:  J P Mounsey; M K Patel; D Mistry; J E John; J R Moorman
Journal:  Br J Pharmacol       Date:  1999-11       Impact factor: 8.739

6.  Sodium channel isoform-specific effects of halothane: protein kinase C co-expression and slow inactivation gating.

Authors:  M K Patel; D Mistry; J E John; J P Mounsey
Journal:  Br J Pharmacol       Date:  2000-08       Impact factor: 8.739

7.  Local anesthetic inhibits hyperpolarization-activated cationic currents.

Authors:  Qing-Tao Meng; Zhong-Yuan Xia; Jin Liu; Douglas A Bayliss; Xiangdong Chen
Journal:  Mol Pharmacol       Date:  2011-02-08       Impact factor: 4.436
  7 in total

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