Literature DB >> 10334995

UDP-GlcNAc 2-epimerase: a regulator of cell surface sialylation.

O T Keppler1, S Hinderlich, J Langner, R Schwartz-Albiez, W Reutter, M Pawlita.   

Abstract

Modification of cell surface molecules with sialic acid is crucial for their function in many biological processes, including cell adhesion and signal transduction. Uridine diphosphate-N-acetylglucosamine 2-epimerase (UDP-GlcNAc 2-epimerase) is an enzyme that catalyzes an early, rate-limiting step in the sialic acid biosynthetic pathway. UDP-GlcNAc 2-epimerase was found to be a major determinant of cell surface sialylation in human hematopoietic cell lines and a critical regulator of the function of specific cell surface adhesion molecules.

Entities:  

Mesh：

Substances：

Year:  1999        PMID： 10334995     DOI： 10.1126/science.284.5418.1372

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  97 in total

1.  Sialylation is essential for early development in mice.

Authors:  Martina Schwarzkopf; Klaus-Peter Knobeloch; Elvira Rohde; Stephan Hinderlich; Nicola Wiechens; Lothar Lucka; Ivan Horak; Werner Reutter; Rüdiger Horstkorte
Journal:  Proc Natl Acad Sci U S A       Date:  2002-04-02       Impact factor: 11.205

2.  Biochemical engineering of cell surface sialic acids stimulates axonal growth.

Authors:  Bettina Büttner; Christoph Kannicht; Carolin Schmidt; Klemens Löster; Werner Reutter; Hye-Youn Lee; Sabine Nöhring; Rüdiger Horstkorte
Journal:  J Neurosci       Date:  2002-10-15       Impact factor: 6.167

3.  Hereditary inclusion body myopathy: single patient response to intravenous dosing of GNE gene lipoplex.

Authors:  Gregory Nemunaitis; Chris M Jay; Phillip B Maples; William A Gahl; Marjan Huizing; Tal Yardeni; Alex W Tong; Anagha P Phadke; Beena O Pappen; Cynthia Bedell; Henry Allen; Cathy Hernandez; Nancy S Templeton; Joseph Kuhn; Neil Senzer; John Nemunaitis
Journal:  Hum Gene Ther       Date:  2011-04-25       Impact factor: 5.695

4.  Domain-specific characteristics of the bifunctional key enzyme of sialic acid biosynthesis, UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase.

Authors:  Astrid Blume; Wenke Weidemann; Ulrich Stelzl; Erich E Wanker; Lothar Lucka; Peter Donner; Werner Reutter; Rüdiger Horstkorte; Stephan Hinderlich
Journal:  Biochem J       Date:  2004-12-15       Impact factor: 3.857

5.  Metabolic flux increases glycoprotein sialylation: implications for cell adhesion and cancer metastasis.

Authors:  Ruben T Almaraz; Yuan Tian; Rahul Bhattarcharya; Elaine Tan; Shih-Hsun Chen; Matthew R Dallas; Li Chen; Zhen Zhang; Hui Zhang; Konstantinos Konstantopoulos; Kevin J Yarema
Journal:  Mol Cell Proteomics       Date:  2012-03-28       Impact factor: 5.911

6.  CD22 is a recycling receptor that can shuttle cargo between the cell surface and endosomal compartments of B cells.

Authors:  Mary K O'Reilly; Hua Tian; James C Paulson
Journal:  J Immunol       Date:  2010-12-22       Impact factor: 5.422

7.  Metabolism of diazirine-modified N-acetylmannosamine analogues to photo-cross-linking sialosides.

Authors:  Michelle R Bond; Haochi Zhang; Jaekuk Kim; Seok-Ho Yu; Fan Yang; Steven M Patrie; Jennifer J Kohler
Journal:  Bioconjug Chem       Date:  2011-08-25       Impact factor: 4.774

8.  Sizing up sialic acid in glomerular disease.

Authors:  Susan E Quaggin
Journal:  J Clin Invest       Date:  2007-06       Impact factor: 14.808

9.  Biochemical characterization of human and murine isoforms of UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE).

Authors:  Stefan O Reinke; Colin Eidenschink; Chris M Jay; Stephan Hinderlich
Journal:  Glycoconj J       Date:  2008-09-23       Impact factor: 2.916

10.  Prophylactic treatment with sialic acid metabolites precludes the development of the myopathic phenotype in the DMRV-hIBM mouse model.

Authors:  May Christine V Malicdan; Satoru Noguchi; Yukiko K Hayashi; Ikuya Nonaka; Ichizo Nishino
Journal:  Nat Med       Date:  2009-06       Impact factor: 53.440
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.