Literature DB >> 10334325

Mutation in the HNF-4alpha gene affects insulin secretion and triglyceride metabolism.

M Lehto1, P O Bitzén, B Isomaa, C Wipemo, Y Wessman, C Forsblom, T Tuomi, M R Taskinen, L Groop.   

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Year:  1999        PMID： 10334325     DOI： 10.2337/diabetes.48.2.423

Source DB:  PubMed          Journal:  Diabetes        ISSN： 0012-1797            Impact factor:   9.461


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  23 in total

1.  Hepatic hepatocyte nuclear factor 4α is essential for maintaining triglyceride and cholesterol homeostasis.

Authors:  Liya Yin; Huiyan Ma; Xuemei Ge; Peter A Edwards; Yanqiao Zhang
Journal:  Arterioscler Thromb Vasc Biol       Date:  2010-11-11       Impact factor: 8.311

2.  Phenotypic heterogeneity between different mutations of MODY subtypes and within MODY pedigrees.

Authors:  S S Fajans; G I Bell
Journal:  Diabetologia       Date:  2006-02-25       Impact factor: 10.122

3.  Single nucleotide polymorphisms of the HNF4alpha gene are associated with the conversion to type 2 diabetes mellitus: the STOP-NIDDM trial.

Authors:  Laura Andrulionyte; Olli Laukkanen; Jean-Louis Chiasson; Markku Laakso
Journal:  J Mol Med (Berl)       Date:  2006-07-13       Impact factor: 4.599

4.  Molecular genetics and phenotypic characteristics of MODY caused by hepatocyte nuclear factor 4alpha mutations in a large European collection.

Authors:  E R Pearson; S Pruhova; C J Tack; A Johansen; H A J Castleden; P J Lumb; A S Wierzbicki; P M Clark; J Lebl; O Pedersen; S Ellard; T Hansen; A T Hattersley
Journal:  Diabetologia       Date:  2005-04-14       Impact factor: 10.122

5.  T130I mutation in HNF-4alpha gene is a loss-of-function mutation in hepatocytes and is associated with late-onset Type 2 diabetes mellitus in Japanese subjects.

Authors:  Q Zhu; K Yamagata; A Miura; N Shihara; Y Horikawa; J Takeda; J Miyagawa; Y Matsuzawa
Journal:  Diabetologia       Date:  2003-03-25       Impact factor: 10.122

6.  Mammalian hepatocyte differentiation requires the transcription factor HNF-4alpha.

Authors:  J Li; G Ning; S A Duncan
Journal:  Genes Dev       Date:  2000-02-15       Impact factor: 11.361

7.  Naturally occurring mutations in the human HNF4alpha gene impair the function of the transcription factor to a varying degree.

Authors:  J Lausen; H Thomas; I Lemm; M Bulman; M Borgschulze; A Lingott; A T Hattersley; G U Ryffel
Journal:  Nucleic Acids Res       Date:  2000-01-15       Impact factor: 16.971

8.  Examination of Rare Variants in HNF4 α in European Americans with Type 2 Diabetes.

Authors:  Jacklyn N Hellwege; Pamela J Hicks; Nicholette D Palmer; Maggie C Y Ng; Barry I Freedman; Donald W Bowden
Journal:  J Diabetes Metab       Date:  2011-10-20

Review 9.  MODY: history, genetics, pathophysiology, and clinical decision making.

Authors:  Stefan S Fajans; Graeme I Bell
Journal:  Diabetes Care       Date:  2011-08       Impact factor: 19.112

10.  The genetic susceptibility to type 2 diabetes may be modulated by obesity status: implications for association studies.

Authors:  Stéphane Cauchi; Kevin T Nead; Hélène Choquet; Fritz Horber; Natascha Potoczna; Beverley Balkau; Michel Marre; Guillaume Charpentier; Philippe Froguel; David Meyre
Journal:  BMC Med Genet       Date:  2008-05-22       Impact factor: 2.103
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