In vitro measurements of water content and T2 relaxation times in lung using a clinical MRI scanner.

The purpose of this study was to validate water content measurements and to determine the T2 distribution in lung on a 1.5 T clinical magnetic resonance imaging (MRI) scanner. A single-slice 16 echo pulse sequence with an echo spacing of 10 msec was employed to scan 19 healthy juvenile pig lungs. The in vitro water content of each lung was measured using MRI techniques and compared with gravimetric measurements. The mean difference between the gravimetric and MRI water contents was -4.1 +/- 7.6%, and an excellent linear correlation (R2 = 0.98) was observed between the two independent measurements. The dependence of the geometric mean T2 time upon lung water density exhibited two distinct regions (inflated and deflated) separated by a threshold density of about 0.4 g/mL.