Literature DB >> 1033071

The bradykinin potentiating activity of two pentapeptides on various isolated smooth muscle preparations.

J G Ufkes, P N Aarsen, C Van Der Meer.   

Abstract

Two bradykinin potentiating peptides A-VI5 (Val-Glu-Ser-Ser-Lys) and BPP5a (Pyr-Lys-Trp-Ala-Pro), were compared with respect to their potentiation of a number of different bradykinin effects on six isolated smooth muscle preparations. Apart from the considerable difference in effective concentrations, no essential qualitative difference was observed between these two peptides. Therefore the assumption of a different mechanism of action for the two peptides, which have a completely different structure, could not be substantiated.

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Year:  1976        PMID： 1033071     DOI： 10.1016/0014-2999(76)90363-0

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  3 in total

1.  Primary structure and biological activity of bradykinin potentiating peptides from Bothrops insularis snake venom.

Authors:  A C Cintra; C A Vieira; J R Giglio
Journal:  J Protein Chem       Date:  1990-04

2.  Further evidence for the existence of two receptor sites for bradykinin responsible for the diphasic effect in the rat isolated duodenum.

Authors:  P Boschcov; A C Paiva; T B Paiva; S I Shimuta
Journal:  Br J Pharmacol       Date:  1984-10       Impact factor: 8.739

3.  The effects of bradykinin and the bradykinin potentiating peptide BPP5a on the electrical and mechanical responses of the guinea-pig taenia coli.

Authors:  P N Aarsen
Journal:  Br J Pharmacol       Date:  1977-12       Impact factor: 8.739
  3 in total

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