| Literature DB >> 10330494 |
H Jiang1, J Sodek, G Karsenty, H Thomas, D Ranly, J Chen.
Abstract
The transcription factor Osf2/Cbfa1 is a key regulator of osteogenic differentiation while BSP, a major non-collagenous protein, is a marker of osteoblastic differentiation. To determine the relationship between Osf2/Cbfa1 and the formation of mineralized tissues in tooth development we have studied the temporal expression of Osf2/Cbfa1 and BSP mRNA using in situ hybridization. These studies show that Osf2/Cbfa1 is expressed early in mesenchymal and epithelial tissues destined to form the mineralized tissues of the tooth and periodontal tissues, whereas BSP provides a specific marker for the differentiated cells in each of these tissues. Expression of Osf2/Cbfa1, but not BSP, was observed in the periodontal ligament indicating that expression of Osf2/Cbfa1 is not restricted to mineralizing tissues.Entities:
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Year: 1999 PMID： 10330494 DOI： 10.1016/s0925-4773(98)00232-9
Source DB: PubMed Journal: Mech Dev ISSN： 0925-4773 Impact factor: 1.882