OBJECTIVE: The aim of the study was to compare maternal serum levels of activin A and inhibin A in pregnancy complicated by preeclampsia, pregnancy complicated by gestational hypertension, and normal pregnancy from 25 to 42 weeks' gestation. STUDY DESIGN: Activin A and inhibin A levels were measured by 2-site enzyme-linked immunosorbent assay in 60 subjects with preeclampsia, 60 control normotensive pregnant women matched for gestational age, and 51 unmatched subjects with gestational hypertension. RESULTS: Activin A levels were higher in the preeclampsia group (median 31.5 ng/mL and interquartile range 10.5 ng/mL) than in the control group (median 10.6 ng/mL and interquartile range 9.5 ng/mL, P <.0001) and the gestational hypertension group (median 21.4 ng/mL and interquartile range 15.2 ng/mL, P <.003). Inhibin A levels were greater in the preeclampsia group (median 1833 pg/mL and interquartile range 1464 pg/mL) than in control subjects (median 698 pg/mL and interquartile range 583 pg/mL, P <.0001). Control levels were significantly related to gestational age. CONCLUSIONS: Levels of both analytes were greater in preeclampsia and activin A levels were greater in gestational hypertension than in normotensive pregnancy. These analytes may prove to be clinically useful laboratory markers for preeclampsia.
OBJECTIVE: The aim of the study was to compare maternal serum levels of activin A and inhibin A in pregnancy complicated by preeclampsia, pregnancy complicated by gestational hypertension, and normal pregnancy from 25 to 42 weeks' gestation. STUDY DESIGN: Activin A and inhibin A levels were measured by 2-site enzyme-linked immunosorbent assay in 60 subjects with preeclampsia, 60 control normotensive pregnant women matched for gestational age, and 51 unmatched subjects with gestational hypertension. RESULTS: Activin A levels were higher in the preeclampsia group (median 31.5 ng/mL and interquartile range 10.5 ng/mL) than in the control group (median 10.6 ng/mL and interquartile range 9.5 ng/mL, P <.0001) and the gestational hypertension group (median 21.4 ng/mL and interquartile range 15.2 ng/mL, P <.003). Inhibin A levels were greater in the preeclampsia group (median 1833 pg/mL and interquartile range 1464 pg/mL) than in control subjects (median 698 pg/mL and interquartile range 583 pg/mL, P <.0001). Control levels were significantly related to gestational age. CONCLUSIONS: Levels of both analytes were greater in preeclampsia and activin A levels were greater in gestational hypertension than in normotensive pregnancy. These analytes may prove to be clinically useful laboratory markers for preeclampsia.
Authors: Linda T Roten; Matthew P Johnson; Siri Forsmo; Elizabeth Fitzpatrick; Thomas D Dyer; Shaun P Brennecke; John Blangero; Eric K Moses; Rigmor Austgulen Journal: Eur J Hum Genet Date: 2008-09-10 Impact factor: 4.246
Authors: E Fitzpatrick; M P Johnson; T D Dyer; S Forrest; K Elliott; J Blangero; S P Brennecke; E K Moses Journal: Mol Hum Reprod Date: 2009-01-06 Impact factor: 4.025
Authors: Hannah E J Yong; Phillip E Melton; Matthew P Johnson; Katy A Freed; Bill Kalionis; Padma Murthi; Shaun P Brennecke; Rosemary J Keogh; Eric K Moses Journal: PLoS One Date: 2015-05-26 Impact factor: 3.240