| Literature DB >> 10328315 |
A K Ganguly1, J L McCormick, A K Saksena, P R Das, T M Chan.
Abstract
Chemical modifications of eveminomicin antibiotics, particularly ziracin (1), were carried out to study the SARs as well as the chemical properties of this class of compounds. Use of allyl ether group for protection and selective deprotection of phenolic groups provided access to a variety of novel analogs of the title compounds, some of which exhibited the same high in vitro potency as the parent compounds.Entities:
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Year: 1999 PMID： 10328315 DOI： 10.1016/s0960-894x(99)00163-8
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823