Literature DB >> 10328302

Conformationally locked nucleosides. Synthesis and hybridization properties of oligodeoxynucleotides containing 2',4'-C-bridged 2'-deoxynucleosides.

G Wang1, E Gunic, J L Girardet, V Stoisavljevic.   

Abstract

A conformationally locked, 2',4'-C-bridged 2'-deoxyribofuranoside2 was condensed with silylated pyrimidines to give 2',4'-C-bridged bicyclonucleosides, which were converted to the phosphoramidites and incorporated into oligodeoxynucleotides (ODNs). The hybridization data of the modified ODNs to DNA and RNA are presented.

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Year:  1999        PMID： 10328302     DOI： 10.1016/s0960-894x(99)00146-8

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  3 in total

1.  An intranasal ASO therapeutic targeting SARS-CoV-2.

Authors:  Chi Zhu; Justin Y Lee; Jia Z Woo; Lei Xu; Xammy Nguyenla; Livia H Yamashiro; Fei Ji; Scott B Biering; Erik Van Dis; Federico Gonzalez; Douglas Fox; Eddie Wehri; Arjun Rustagi; Benjamin A Pinsky; Julia Schaletzky; Catherine A Blish; Charles Chiu; Eva Harris; Ruslan I Sadreyev; Sarah Stanley; Sakari Kauppinen; Silvi Rouskin; Anders M Näär
Journal:  Nat Commun       Date:  2022-08-03       Impact factor: 17.694

2.  A bridged nucleic acid, 2',4'-BNA COC: synthesis of fully modified oligonucleotides bearing thymine, 5-methylcytosine, adenine and guanine 2',4'-BNA COC monomers and RNA-selective nucleic-acid recognition.

Authors:  Yasunori Mitsuoka; Tetsuya Kodama; Ryo Ohnishi; Yoshiyuki Hari; Takeshi Imanishi; Satoshi Obika
Journal:  Nucleic Acids Res       Date:  2009-01-09       Impact factor: 16.971

3.  Discovery of herpesviruses in multi-infected primates using locked nucleic acids (LNA) and a bigenic PCR approach.

Authors:  Sandra Prepens; Karl-Anton Kreuzer; Fabian Leendertz; Andreas Nitsche; Bernhard Ehlers
Journal:  Virol J       Date:  2007-09-06       Impact factor: 4.099
  3 in total

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