Literature DB >> 10323583

Functional evidence of alpha1D-adrenoceptors in the vasculature of young and adult spontaneously hypertensive rats.

R Villalobos-Molina1, J J López-Guerrero, M Ibarra.   

Abstract

The role of alpha1D-adrenoceptors in the vasculature of spontaneously hypertensive (SHR) and normotensive Wistar Kyoto rats (WKY), of different ages was assessed in pithed rats by the use of the selective alpha1D-adrenoceptor antagonist BMY 7378 (8-[2-[4-(2-methoxyphenyl)-1-piperazinyl]-ethyl]-8-azaspiro [4.5]decane-7,9-dione dihydrochloride). BMY 7378 displaced the pressor effect of phenylephrine in young pre-hypertensive pithed SHR rats, but produced no effect in young WKY rats (dose ratio of 3.4 and 1.6, respectively), while in adult rats BMY 7378 produced a greater shift in the phenylephrine response curve than in younger animals (dose ratio of 3.2 and 6.2 in WKY and SHR, respectively). The presence of alpha1D-adrenoceptors in the vasculature of pre-hypertensive rats, suggests its role in the pathogenesis/maintenance of increased blood pressure.

Entities:  

Mesh：

Substances：

Year:  1999        PMID： 10323583      PMCID： PMC1565938          DOI： 10.1038/sj.bjp.0702468

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  9 in total

1.  Is alpha1D-adrenoceptor protein detectable in rat tissues?

Authors:  M Yang; F Verfürth; R Büscher; M C Michel
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1997-04       Impact factor: 3.000

2.  Alteration of alpha1-adrenoceptor subtypes in aortas of 12-month-old spontaneously hypertensive rats.

Authors:  K Xu; Z Lu; H Wei; Y Zhang; C Han
Journal:  Eur J Pharmacol       Date:  1998-02-26       Impact factor: 4.432

3.  Characterization of alpha 1 D-adrenoceptor subtype in rat myocardium, aorta and other tissues.

Authors:  X F Deng; S Chemtob; D R Varma
Journal:  Br J Pharmacol       Date:  1996-09       Impact factor: 8.739

Review 4.  International Union of Pharmacology. X. Recommendation for nomenclature of alpha 1-adrenoceptors: consensus update.

Authors:  J P Hieble; D B Bylund; D E Clarke; D C Eikenburg; S Z Langer; R J Lefkowitz; K P Minneman; R R Ruffolo
Journal:  Pharmacol Rev       Date:  1995-06       Impact factor: 25.468

5.  Evidence for an age-dependent functional expression of alpha 1D-adrenoceptors in the rat vasculature.

Authors:  M Ibarra; J A Terrón; J J López-Guerrero; R Villalobos-Molina
Journal:  Eur J Pharmacol       Date:  1997-03-19       Impact factor: 4.432

6.  Immunocytochemical localization of the alpha-1B adrenergic receptor and the contribution of this and the other subtypes to vascular smooth muscle contraction: analysis with selective ligands and antisense oligonucleotides.

Authors:  M T Piascik; S L Hrometz; S E Edelmann; R D Guarino; R W Hadley; R D Brown
Journal:  J Pharmacol Exp Ther       Date:  1997-11       Impact factor: 4.030

7.  Vascular alpha 1D-adrenoceptors have a role in the pressor response to phenylephrine in the pithed rat.

Authors:  L Zhou; H M Vargas
Journal:  Eur J Pharmacol       Date:  1996-06-03       Impact factor: 4.432

8.  Alpha 1-adrenoceptors mediating contraction in arteries of normotensive and spontaneously hypertensive rats are of the alpha 1D or alpha 1A subtypes.

Authors:  R Villalobos-Molina; M Ibarra
Journal:  Eur J Pharmacol       Date:  1996-03-18       Impact factor: 4.432

9.  Alpha 1-adrenoceptor subtypes in rat aorta and mesenteric small arteries are preserved during left ventricular dysfunction post-myocardial infarction.

Authors:  F R Stassen; M J Willemsen; G M Janssen; J G DeMey
Journal:  Cardiovasc Res       Date:  1997-03       Impact factor: 10.787
  9 in total
  12 in total

1.  Signaling properties of human alpha(1D)-adrenoceptors lacking the carboxyl terminus: intrinsic activity, agonist-mediated activation, and desensitization.

Authors:  C Ekaterina Rodríguez-Pérez; M Teresa Romero-Avila; Guadalupe Reyes-Cruz; J Adolfo García-Sáinz
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2009-05-21       Impact factor: 3.000

Review 2.  Updates in the function and regulation of α1 -adrenoceptors.

Authors:  Juliana Akinaga; J Adolfo García-Sáinz; André S Pupo
Journal:  Br J Pharmacol       Date:  2019-04-01       Impact factor: 8.739

3.  The alpha(1D)-adrenergic receptor directly regulates arterial blood pressure via vasoconstriction.

Authors:  Akito Tanoue; Yoshihisa Nasa; Takaaki Koshimizu; Hitomi Shinoura; Sayuri Oshikawa; Takayuki Kawai; Sachie Sunada; Satoshi Takeo; Gozoh Tsujimoto
Journal:  J Clin Invest       Date:  2002-03       Impact factor: 14.808

4.  Evidence for involvement of alpha1D-adrenoceptors in contraction of femoral resistance arteries using knockout mice.

Authors:  Joseph Zacharia; Chris Hillier; Akito Tanoue; Gozoh Tsujimoto; Craig J Daly; John C McGrath; Allan MacDonald
Journal:  Br J Pharmacol       Date:  2005-12       Impact factor: 8.739

5.  Pathological role of a constitutively active population of alpha(1D)-adrenoceptors in arteries of spontaneously hypertensive rats.

Authors:  Regina Gisbert; Khalid Ziani; Raquel Miquel; M Antonia Noguera; M Dolores Ivorra; Elsa Anselmi; Pilar D'Ocon
Journal:  Br J Pharmacol       Date:  2002-01       Impact factor: 8.739

6.  Functional characterization of alpha(1)-adrenoceptor subtypes in human skeletal muscle resistance arteries.

Authors:  Y P Jarajapu; P Coats; J C McGrath; C Hillier; A MacDonald
Journal:  Br J Pharmacol       Date:  2001-07       Impact factor: 8.739

7.  Phosphorylation and desensitization of alpha1d-adrenergic receptors.

Authors:  J A García-Sáinz; F G Vázquez-Cuevas; M T Romero-Avila
Journal:  Biochem J       Date:  2001-02-01       Impact factor: 3.857

8.  Phospholipase C-delta1 modulates sustained contraction of rat mesenteric small arteries in response to noradrenaline, but not endothelin-1.

Authors:  Christopher J Clarke; Simon Forman; James Pritchett; Vasken Ohanian; Jacqueline Ohanian
Journal:  Am J Physiol Heart Circ Physiol       Date:  2008-06-20       Impact factor: 4.733

9.  Vascular alpha-1D-adrenoceptors are overexpressed in aorta of the aryl hydrocarbon receptor null mouse: role of increased angiotensin II.

Authors:  R Villalobos-Molina; F G Vázquez-Cuevas; J J López-Guerrero; M C Figueroa-García; I A Gallardo-Ortiz; M Ibarra; M Rodríguez-Sosa; F J Gonzalez; G Elizondo
Journal:  Auton Autacoid Pharmacol       Date:  2008 Apr-Jul

10.  Carboxyl terminus-truncated α1D-adrenoceptors inhibit the ERK pathway.

Authors:  Marco A Alfonzo-Méndez; Jean A Castillo-Badillo; M Teresa Romero-Ávila; Richard Rivera; Jerold Chun; J Adolfo García-Sáinz
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2016-05-05       Impact factor: 3.000
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.