Literature DB >> 10323491

Anticomplement activity of triterpenes from Crataeva nurvala stem bark in adjuvant arthritis in rats.

T Geetha1, P Varalakshmi.   

Abstract

Adjuvant arthritis is widely used as an experimental model for rheumatoid arthritis and inflammation. It is useful in the evaluation of anti-inflammatory drugs. Lupeol is a naturally occuring triterpene isolated from Crataeva nurvala stem bark, and its ester lupeol linoleate was synthesized. The effects of lupeol and lupeol linoleate on the development of complement in adjuvant arthritis in rats were studied and compared with those of indomethacin. The effect of lupeol linoleate in reducing the foot-pad thickness and complement activity in arthritic rats was even greater than that of unesterified lupeol and indomethacin. Because complement is highly involved in inflammation, the results suggest that the anti-inflammatory activity of triterpenes may be due to their anticomplementary activity.

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Year:  1999        PMID： 10323491     DOI： 10.1016/s0306-3623(98)00212-2

Source DB:  PubMed          Journal:  Gen Pharmacol        ISSN： 0306-3623


  11 in total

1.  Naturally occurring compounds affect glutamatergic neurotransmission in rat brain.

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Journal:  Neurochem Res       Date:  2007-06-19       Impact factor: 3.996

2.  MT1-MMP expression level status dictates the in vitro action of lupeol on inflammatory biomarkers MMP-9 and COX-2 in medulloblastoma cells.

Authors:  Borhane Annabi; Eric Vaillancourt-Jean; Richard Béliveau
Journal:  Inflammopharmacology       Date:  2012-06-16       Impact factor: 4.473

Review 3.  Modulation of Wnt/β-catenin signaling pathway by bioactive food components.

Authors:  Rohinton S Tarapore; Imtiaz A Siddiqui; Hasan Mukhtar
Journal:  Carcinogenesis       Date:  2011-12-22       Impact factor: 4.944

Review 4.  Lupeol, a novel anti-inflammatory and anti-cancer dietary triterpene.

Authors:  Mohammad Saleem
Journal:  Cancer Lett       Date:  2009-05-22       Impact factor: 8.679

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Authors:  Jihang Chen; Hoi Shan Wong; Pou Kuan Leong; Hoi Yan Leung; Wing Man Chan; Kam Ming Ko
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6.  Anti-arthritic Effects of Total Flavonoids from Juniperus sabina on Complete Freund's Adjuvant Induced Arthritis in Rats.

Authors:  Jun Zhao; Tao Liu; Fang Xu; Shuping You; Fang Xu; Chenyang Li; Zhengyi Gu
Journal:  Pharmacogn Mag       Date:  2016 Jul-Sep       Impact factor: 1.085

7.  Shea Nut Oil Triterpene Concentrate Attenuates Knee Osteoarthritis Development in Rats: Evidence from Knee Joint Histology.

Authors:  Jen-Hsin Kao; Sheng-Hsiung Lin; Chun-Fu Lai; Yu-Chieh Lin; Zwe-Ling Kong; Chih-Shung Wong
Journal:  PLoS One       Date:  2016-09-01       Impact factor: 3.240

8.  Anti-arthritic property of crude extracts of Piptadeniastrum africanum (Mimosaceae) in complete Freund's adjuvant-induced arthritis in rats.

Authors:  Marius Mbiantcha; Jabeen Almas; Simjee U Shabana; Dastagir Nida; Faheem Aisha
Journal:  BMC Complement Altern Med       Date:  2017-02-15       Impact factor: 3.659

Review 9.  Phytochemicals as modulators of M1-M2 macrophages in inflammation.

Authors:  Uzma Saqib; Sutripta Sarkar; Kyoungho Suk; Owais Mohammad; Mirza S Baig; Rajkumar Savai
Journal:  Oncotarget       Date:  2018-04-03

10.  Urox containing concentrated extracts of Crataeva nurvala stem bark, Equisetum arvense stem and Lindera aggregata root, in the treatment of symptoms of overactive bladder and urinary incontinence: a phase 2, randomised, double-blind placebo controlled trial.

Authors:  Niikee Schoendorfer; Nita Sharp; Tracey Seipel; Alexander G Schauss; Kiran D K Ahuja
Journal:  BMC Complement Altern Med       Date:  2018-01-31       Impact factor: 3.659
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