AIM: To study the effect of melatonin on hydroxyl radical (.OH) contents during cerebral ischemia-reperfusion in rats. METHODS: Ischemia was induced by occluding left lateral middle cerebral artery for 30 min following reperfusion. The salicylate trapping method coupled with ipsilateral striatal microdialysis for measurement of hydroxyl radicals generated during ischemia and reperfusion. RESULTS: The contents of dihydroxybenzoic acid (DHBA) were increased at 15 min after ischemia and remained high for 30 min after reperfusion. Melatonin (4 mg.kg-1, sc, 30 min before ischemia) decreased the production of DHBA during ischemia for 16-30 min and reperfusion for 1-30 min. CONCLUSION: Melatonin inhibits the production of hydroxyl radicals in rat brain during ischemia and reperfusion.
AIM: To study the effect of melatonin on hydroxyl radical (.OH) contents during cerebral ischemia-reperfusion in rats. METHODS:Ischemia was induced by occluding left lateral middle cerebral artery for 30 min following reperfusion. The salicylate trapping method coupled with ipsilateral striatal microdialysis for measurement of hydroxyl radicals generated during ischemia and reperfusion. RESULTS: The contents of dihydroxybenzoic acid (DHBA) were increased at 15 min after ischemia and remained high for 30 min after reperfusion. Melatonin (4 mg.kg-1, sc, 30 min before ischemia) decreased the production of DHBA during ischemia for 16-30 min and reperfusion for 1-30 min. CONCLUSION:Melatonin inhibits the production of hydroxyl radicals in rat brain during ischemia and reperfusion.
Authors: Yalikun Suofu; Wei Li; Frédéric G Jean-Alphonse; Jiaoying Jia; Nicolas K Khattar; Jiatong Li; Sergei V Baranov; Daniela Leronni; Amanda C Mihalik; Yanqing He; Erika Cecon; Vanessa L Wehbi; JinHo Kim; Brianna E Heath; Oxana V Baranova; Xiaomin Wang; Matthew J Gable; Eric S Kretz; Giulietta Di Benedetto; Timothy R Lezon; Lisa M Ferrando; Timothy M Larkin; Mara Sullivan; Svitlana Yablonska; Jingjing Wang; M Beth Minnigh; Gérald Guillaumet; Franck Suzenet; R Mark Richardson; Samuel M Poloyac; Donna B Stolz; Ralf Jockers; Paula A Witt-Enderby; Diane L Carlisle; Jean-Pierre Vilardaga; Robert M Friedlander Journal: Proc Natl Acad Sci U S A Date: 2017-09-05 Impact factor: 11.205
Authors: Dun-Xian Tan; Lucien C Manchester; Rosa M Sainz; Juan C Mayo; Josefa León; Russel J Reiter Journal: Endocrine Date: 2005-07 Impact factor: 3.633