AIM: To evaluate the effects of total coumarins from dried fruits of Cnidium monnieri (TCCM) on glucocorticoids (GC)-induced osteoporosis (OP) in rats. METHODS: Single photon absorptiometric and biomechanical character measurements of femurs were used. RESULTS: The bone density (BD) indices in proximal, middle, and distal segments in GC group were decreased by 12% (P < 0.05), 14% (P < 0.05), and 12% (P < 0.05), respectively vs control group. The BD on proximal, middle, and distal segments in GC-TCCM group were increased by 26% (P < 0.01), 34% (P < 0.01), and 31% (P < 0.01), respectively vs GC group. The biomechanical competence in femoral middle segments in GC group tended to decrease vs control group. In GC-TCCM group, the torsional strength, energy, maximal torsional angle, and rigidity were increased by 15% (P < 0.05), 32% (P < 0.05), 14% (P > 0.05), and 13% (P > 0.05), respectively vs the GC group. CONCLUSION: TCCM not only prevented glucocorticoids-induced osteoporosis but also increased the torsional strength of femurs in rats.
AIM: To evaluate the effects of total coumarins from dried fruits of Cnidium monnieri (TCCM) on glucocorticoids (GC)-induced osteoporosis (OP) in rats. METHODS: Single photon absorptiometric and biomechanical character measurements of femurs were used. RESULTS: The bone density (BD) indices in proximal, middle, and distal segments in GC group were decreased by 12% (P < 0.05), 14% (P < 0.05), and 12% (P < 0.05), respectively vs control group. The BD on proximal, middle, and distal segments in GC-TCCM group were increased by 26% (P < 0.01), 34% (P < 0.01), and 31% (P < 0.01), respectively vs GC group. The biomechanical competence in femoral middle segments in GC group tended to decrease vs control group. In GC-TCCM group, the torsional strength, energy, maximal torsional angle, and rigidity were increased by 15% (P < 0.05), 32% (P < 0.05), 14% (P > 0.05), and 13% (P > 0.05), respectively vs the GC group. CONCLUSION:TCCM not only prevented glucocorticoids-induced osteoporosis but also increased the torsional strength of femurs in rats.
Authors: R T Turner; A Maran; S Lotinun; T Hefferan; G L Evans; M Zhang; J D Sibonga Journal: Rev Endocr Metab Disord Date: 2001-01 Impact factor: 6.514
Authors: Zhong-Rong Zhang; Wing Nang Leung; Ho Yee Cheung; Chun Wai Chan Journal: Evid Based Complement Alternat Med Date: 2015-07-13 Impact factor: 2.629