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Literature DB >> 10322419

Retinoblastoma protein meets chromatin.

Abstract

The retinoblastoma (RB) protein exerts its tumour-suppressor function by repressing the transcription of cellular genes required for DNA replication and cell division. Recent investigations into the mechanism of RB repression have revealed that RB can regulate transcription by effecting changes in chromatin structure. These findings point towards a link between chromatin regulation and cancer.

Entities: Disease Gene

Mesh：

Substances：

Year: 1999 PMID： 10322419 DOI： 10.1016/s0968-0004(99)01368-7

Source DB: PubMed Journal: Trends Biochem Sci ISSN： 0968-0004 Impact factor: 13.807

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Cited

50 in total

Review 1. Retinoblastoma proteins in plants.

Authors: S M de Jager; J A Murray
Journal: Plant Mol Biol Date: 1999-10 Impact factor: 4.076

2. Temporal recruitment of the mSin3A-histone deacetylase corepressor complex to the ETS domain transcription factor Elk-1.

Authors: S H Yang; E Vickers; A Brehm; T Kouzarides; A D Sharrocks
Journal: Mol Cell Biol Date: 2001-04 Impact factor: 4.272

Review 3. DNA replication and cell cycle in plants: learning from geminiviruses.

Authors: C Gutierrez
Journal: EMBO J Date: 2000-03-01 Impact factor: 11.598

4. J domain-independent regulation of the Rb family by polyomavirus large T antigen.

Authors: Q Sheng; T M Love; B Schaffhausen
Journal: J Virol Date: 2000-06 Impact factor: 5.103

Review 5. Chromatin modification and disease.

Authors: C A Johnson
Journal: J Med Genet Date: 2000-12 Impact factor: 6.318

Retinoblastoma protein meets chromatin.

Review 1. Retinoblastoma proteins in plants.

2. Temporal recruitment of the mSin3A-histone deacetylase corepressor complex to the ETS domain transcription factor Elk-1.

Review 3. DNA replication and cell cycle in plants: learning from geminiviruses.

4. J domain-independent regulation of the Rb family by polyomavirus large T antigen.

Review 5. Chromatin modification and disease.

6. Establishment of irreversible growth arrest in myogenic differentiation requires the RB LXCXE-binding function.

7. Involvement of retinoblastoma protein and HBP1 in histone H1(0) gene expression.

8. Retinoblastoma protein disrupts interactions required for RNA polymerase III transcription.

9. Reversal of human cellular senescence: roles of the p53 and p16 pathways.

10. Distinct mechanisms of E2F regulation by Drosophila RBF1 and RBF2.