Literature DB >> 10322388

Mechanisms by which Thiazolidinediones Enhance Insulin Action.

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Abstract

Thiazolidinediones (TZDs) are an exciting new class of insulin-sensitizing drugs being used currently for the treatment of non-insulin-dependent diabetes mellitus. The molecular target of these compounds is thought to be the nuclear hormone receptor, peroxisome proliferator-activated receptor gamma (PPARgamma). PPARgamma is expressed predominantly in adipose tissue, yet a major site of TZD-responsive glucose disposal is skeletal muscle. Potential explanations for this paradox are discussed in this review.

Entities:  

Year:  1999        PMID： 10322388     DOI： 10.1016/s1043-2760(98)00110-6

Source DB:  PubMed          Journal:  Trends Endocrinol Metab        ISSN： 1043-2760            Impact factor:   12.015


  13 in total

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Review 4.  Molecular mechanism of insulin resistance in obesity and type 2 diabetes.

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5.  Regulation of uncoupling protein-2 mRNA in L6 myotubules: I: Thiazolidinediones stimulate uncoupling protein-2 gene expression by a mechanism requiring ongoing protein synthesis and an active mitogen-activated protein kinase.

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6.  Preparation and characterization of pioglitazone cyclodextrin inclusion complexes.

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Review 8.  Recent Advances in Astragalus membranaceus Anti-Diabetic Research: Pharmacological Effects of Its Phytochemical Constituents.

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9.  Mitochondrial dysfunction has divergent, cell type-dependent effects on insulin action.

Authors:  Sheree D Martin; Shona Morrison; Nicky Konstantopoulos; Sean L McGee
Journal:  Mol Metab       Date:  2014-03-12       Impact factor: 7.422

10.  Molecular mechanism of thiazolidinedione-mediated inhibitory effects on osteoclastogenesis.

Authors:  Dongfeng Zhao; Zhenqi Shi; Amy H Warriner; Ping Qiao; Huixian Hong; Yongjun Wang; Xu Feng
Journal:  PLoS One       Date:  2014-07-17       Impact factor: 3.240
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