| Literature DB >> 10322152 |
H von Boehmer1, I Aifantis, J Feinberg, O Lechner, C Saint-Ruf, U Walter, J Buer, O Azogui.
Abstract
The construction of various gene-deficient mice has facilitated the understanding of the role of various receptors and signaling pathways that control the generation of alphabeta lineage cells. A predominant role is occupied by the pre-TCR, which not only generates large numbers of alphabeta lineage cells but also controls TCRbeta allelic exclusion as well as commitment to the gammadelta lineage versus the alphabeta lineage.Entities:
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Year: 1999 PMID： 10322152 DOI： 10.1016/s0952-7915(99)80024-7
Source DB: PubMed Journal: Curr Opin Immunol ISSN： 0952-7915 Impact factor: 7.486