Literature DB >> 10322149

Convergent peptide libraries, or mixotopes, to elicit or to identify specific immune responses.

H Gras-Masse1, B Georges, J Estaquier, D Tranchand-Bunel, A Tartar, P Druilhe, C Auriault.   

Abstract

Many recent studies have demonstrated the flexibility of epitope recognition by the immune system. This can be explored using a particular type of combinatorial peptide library, termed as 'convergent', consisting essentially of closely related molecular species; from this a fuzzy set can be constructed, which comprises several variants of a peptide that would act in synchrony to represent a model antigen and its recognition by the immune system.

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Year:  1999        PMID: 10322149     DOI: 10.1016/s0952-7915(99)80038-7

Source DB:  PubMed          Journal:  Curr Opin Immunol        ISSN: 0952-7915            Impact factor:   7.486


  1 in total

1.  Evaluation of an Epstein-Barr virus (EBV) immunoglobulin M enzyme-linked immunosorbent assay using a synthetic convergent peptide library, or mixotope, for diagnosis of primary EBV infection.

Authors:  D Tranchand-Bunel; H Gras-Masse; B Bourez; L Dedecker; C Auriault
Journal:  J Clin Microbiol       Date:  1999-07       Impact factor: 5.948

  1 in total

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