Literature DB >> 10322129

Touching the heart of HIV-1 drug resistance: the fingers close down on the dNTP at the polymerase active site.

S G Sarafianos1, K Das, J Ding, P L Boyer, S H Hughes, E Arnold.   

Abstract

Comparison of the recently solved structure of HIV-1 reverse transcriptase (RT)-DNA-dNTP ternary complex with the previously solved structure of RT-DNA binary complex suggests mechanisms by which the HIV-1 RT becomes resistant to nucleoside-analog inhibitors, drugs currently used in the treatment of AIDS.

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Year:  1999        PMID： 10322129     DOI： 10.1016/s1074-5521(99)80071-4

Source DB:  PubMed          Journal:  Chem Biol        ISSN： 1074-5521


  43 in total

1.  4'-Ethynyl nucleoside analogs: potent inhibitors of multidrug-resistant human immunodeficiency virus variants in vitro.

Authors:  E I Kodama; S Kohgo; K Kitano; H Machida; H Gatanaga; S Shigeta; M Matsuoka; H Ohrui; H Mitsuya
Journal:  Antimicrob Agents Chemother       Date:  2001-05       Impact factor: 5.191

Review 2.  Molecular impact of the M184V mutation in human immunodeficiency virus type 1 reverse transcriptase.

Authors:  Karidia Diallo; Matthias Götte; M A Wainberg
Journal:  Antimicrob Agents Chemother       Date:  2003-11       Impact factor: 5.191

Review 3.  Conformational changes in HIV-1 reverse transcriptase induced by nonnucleoside reverse transcriptase inhibitor binding.

Authors:  Nicolas Sluis-Cremer; N Alpay Temiz; Ivet Bahar
Journal:  Curr HIV Res       Date:  2004-10       Impact factor: 1.581

4.  A Guide to HIV-1 Reverse Transcriptase and Protease Sequencing for Drug Resistance Studies.

Authors:  Robert W Shafer; Kathryn Dupnik; Mark A Winters; Susan H Eshleman
Journal:  HIV Seq Compend       Date:  2001

5.  Nucleotide-dependent conformational change governs specificity and analog discrimination by HIV reverse transcriptase.

Authors:  Matthew W Kellinger; Kenneth A Johnson
Journal:  Proc Natl Acad Sci U S A       Date:  2010-04-12       Impact factor: 11.205

6.  The Genetic Basis of HIV-1 Resistance to Reverse Transcriptase and Protease Inhibitors.

Authors:  Robert W Shafer; Rami Kantor; Matthew J Gonzales
Journal:  AIDS Rev       Date:  2000       Impact factor: 2.500

7.  Formation of a quaternary complex of HIV-1 reverse transcriptase with a nucleotide-competing inhibitor and its ATP enhancer.

Authors:  Maryam Ehteshami; Monique Nijhuis; Jean A Bernatchez; Christopher J Ablenas; Suzanne McCormick; Dorien de Jong; Dirk Jochmans; Matthias Götte
Journal:  J Biol Chem       Date:  2013-04-18       Impact factor: 5.157

8.  Selection and characterization of Autographa californica multiple nucleopolyhedrovirus DNA polymerase mutations.

Authors:  Guozhong Feng; David K Thumbi; Jondavid de Jong; Jeffrey J Hodgson; Basil M Arif; Daniel Doucet; Peter J Krell
Journal:  J Virol       Date:  2012-10-03       Impact factor: 5.103

9.  The reverse transcriptase sequence of human immunodeficiency virus type 1 is under positive evolutionary selection within the central nervous system.

Authors:  Kelly J Huang; Gerald M Alter; Dawn P Wooley
Journal:  J Neurovirol       Date:  2002-08       Impact factor: 2.643

10.  Iminodiacetic-phosphoramidates as metabolic prototypes for diversifying nucleic acid polymerization in vivo.

Authors:  Anne Giraut; Xiao-ping Song; Matheus Froeyen; Philippe Marlière; Piet Herdewijn
Journal:  Nucleic Acids Res       Date:  2010-01-22       Impact factor: 16.971
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