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Literature DB >> 10320775

Isolation and characterization of a mouse SRY-related cDNA, mSox7.

K Taniguchi¹, Y Hiraoka, M Ogawa, Y Sakai, S Kido, S Aiso.

Abstract

SOX is a family of SRY-related genes, which encode transcriptional factors involved in development. In this study, we newly isolated and sequenced mouse cDNA clones for mSox7. The mSox7 gene encodes 380 amino acids containing an SRY-type HMG box. Genomic Southern analysis suggested that the mSox7 gene was a single-copy gene. Tissue specific expression of mSox7 was investigated by Northern analysis. The expression was restricted to the ovary and heart, and the size of the transcripts was estimated to be 3.6 knt. Electrophoretic mobility shift assay indicated that recombinant mSox7 polypeptide was capable of binding to a nucleotide sequence, AACAAT. Immunohistochemical study revealed that mSox7 protein was localized in oocytes in the mouse ovary.

Entities: Disease Gene Species

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Year: 1999 PMID： 10320775 DOI： 10.1016/s0167-4781(99)00047-0

Source DB: PubMed Journal: Biochim Biophys Acta ISSN： 0006-3002

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Cited

12 in total

1. Mouse model reveals the role of SOX7 in the development of congenital diaphragmatic hernia associated with recurrent deletions of 8p23.1.

Authors: Margaret J Wat; Tyler F Beck; Andrés Hernández-García; Zhiyin Yu; Danielle Veenma; Monica Garcia; Ashley M Holder; Jeanette J Wat; Yuqing Chen; Carrie A Mohila; Kevin P Lally; Mary Dickinson; Dick Tibboel; Annelies de Klein; Brendan Lee; Daryl A Scott
Journal: Hum Mol Genet Date: 2012-06-20 Impact factor: 6.150

2. A potential relationship among beta-defensins haplotype, SOX7 duplication and cardiac defects.

Authors: Fei Long; Xike Wang; Shaohai Fang; Yuejuan Xu; Kun Sun; Sun Chen; Rang Xu
Journal: PLoS One Date: 2013-08-29 Impact factor: 3.240

3. Sox18 preserves the pulmonary endothelial barrier under conditions of increased shear stress.

Authors: Christine M Gross; Saurabh Aggarwal; Sanjiv Kumar; Jing Tian; Anita Kasa; Natalia Bogatcheva; Sanjeev A Datar; Alexander D Verin; Jeffrey R Fineman; Stephen M Black
Journal: J Cell Physiol Date: 2014-11 Impact factor: 6.384

4. SOX7 transcription factor: sequence, chromosomal localisation, expression, transactivation and interference with Wnt signalling.

Authors: W Takash; J Cañizares; N Bonneaud; F Poulat; M G Mattéi; P Jay; P Berta
Journal: Nucleic Acids Res Date: 2001-11-01 Impact factor: 16.971

Isolation and characterization of a mouse SRY-related cDNA, mSox7.

1. Mouse model reveals the role of SOX7 in the development of congenital diaphragmatic hernia associated with recurrent deletions of 8p23.1.

2. A potential relationship among beta-defensins haplotype, SOX7 duplication and cardiac defects.

3. Sox18 preserves the pulmonary endothelial barrier under conditions of increased shear stress.

4. SOX7 transcription factor: sequence, chromosomal localisation, expression, transactivation and interference with Wnt signalling.

5. SOX7 and SOX18 are essential for cardiogenesis in Xenopus.

6. Chromosome 8p23.1 deletions as a cause of complex congenital heart defects and diaphragmatic hernia.

7. Lineage specification of Flk-1+ progenitors is associated with divergent Sox7 expression in cardiopoiesis.

8. Impact of SOX18 expression in cancer cells and vessels on the outcome of invasive ductal breast carcinoma.

Review 9. Role of the SOX18 protein in neoplastic processes.

Review 10. Control of cell fate and differentiation by Sry-related high-mobility-group box (Sox) transcription factors.