| Literature DB >> 1031954 |
A B Boink, T J Ruigrok, A H Maas, A N Zimmerman.
Abstract
When isolated rat hearts are perfused with Ca2+-containing medium, after a brief Ca2+-free period, irreversible cell damage occurs (calcium paradox). This phenomenon is concomitant with a rapid consumption of myocardial high-energy phosphate stores, prior to the appearance of these compounds in the effluent perfusion medium. A possible mechanism for the origin of myocardial necrosis, caused by intracellular Ca2+ overload, is discussed.Entities:
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Year: 1976 PMID： 1031954
Source DB: PubMed Journal: Recent Adv Stud Cardiac Struct Metab ISSN： 0363-5872