| Literature DB >> 10319271 |
T U Vogel1, D T Evans, J A Urvater, D H O'Connor, A L Hughes, D I Watkins.
Abstract
The major histocompatibility complex (MHC) is the most polymorphic genetic system known, playing a central role in the cellular immune response to pathogens. The relationship between the MHC of humans and non-human primates has increased our understanding of MHC evolution and how polymorphism of this gene family may have been generated. We will review MHC class I evolution in great apes and Old World and New World primates and discuss new data from the simian immunodeficiency virus/rhesus monkey animal model that demonstrate the role of MHC class I alleles in selecting for new populations of viruses. This suggests that certain pathogens co-evolve with the MHC class I molecules they encounter in a population.Entities:
Mesh：
Year: 1999 PMID： 10319271 DOI： 10.1111/j.1600-065x.1999.tb01402.x
Source DB: PubMed Journal: Immunol Rev ISSN： 0105-2896 Impact factor: 12.988