Literature DB >> 10319143

Synthesis of antihypertensive agents via coupling reaction of benzothiazepinone and 1,4-dihydropyridine derivatives.

W H Ham1, J G Yang, T G Lim, Y H Jung, Y S Chung.   

Abstract

The synthesis of 3a, 3b, 7a and 7b from Benzothiazepinone and 1,4-dihyropyridine derivatives is described. Benzothiazepinone and 1,4-dihydropyridine derivatives were prepared according to literature procedure. The key reactions involve esterification and amidation of benzothiazepinone and 1,4-dihydropyridine derivatives.

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Year:  1994        PMID： 10319143     DOI： 10.1007/bf02974235

Source DB:  PubMed          Journal:  Arch Pharm Res        ISSN： 0253-6269            Impact factor:   4.946


  7 in total

1.  Synthesis of halogen-substituted 1,5-benzothiazepine derivatives and their vasodilating and hypotensive activities.

Authors:  H Inoue; M Konda; T Hashiyama; H Otsuka; K Takahashi; M Gaino; T Date; K Aoe; M Takeda; S Murata
Journal:  J Med Chem       Date:  1991-02       Impact factor: 7.446

Review 2.  Calcium channel ligands.

Authors:  D J Triggle; R A Janis
Journal:  Annu Rev Pharmacol Toxicol       Date:  1987       Impact factor: 13.820

Review 3.  Increased free intracellular Ca2+ by toxic agents: an index of potential neurotoxicity?

Authors:  H Komulainen; S C Bondy
Journal:  Trends Pharmacol Sci       Date:  1988-05       Impact factor: 14.819

4.  Interrelationship between Na+ and Ca2+ metabolism in hypertension.

Authors:  A Abbott
Journal:  Trends Pharmacol Sci       Date:  1988-04       Impact factor: 14.819

5.  Voltage-dependent block of calcium channel current in the calf cardiac Purkinje fiber by dihydropyridine calcium channel antagonists.

Authors:  M C Sanguinetti; R S Kass
Journal:  Circ Res       Date:  1984-09       Impact factor: 17.367

6.  A new class of calcium antagonists. 2. Synthesis and biological activity of 11-[[4-[4-(4-fluorophenyl)-1-piperazinyl]butyryl]amino]-6,11- dihydrodibenzo[b,e]-thiepin maleate and related compounds.

Authors:  M Kurokawa; F Sato; I Fujiwara; N Hatano; Y Honda; T Yoshida; S Naruto; J Mastumoto; H Uno
Journal:  J Med Chem       Date:  1991-03       Impact factor: 7.446

7.  Benzazepinone calcium channel blockers. 2. Structure-activity and drug metabolism studies leading to potent antihypertensive agents. Comparison with benzothiazepinones.

Authors:  D M Floyd; S D Kimball; J Krapcho; J Das; C F Turk; R V Moquin; M W Lago; K J Duff; V G Lee; R E White
Journal:  J Med Chem       Date:  1992-02-21       Impact factor: 7.446
  7 in total

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