Literature DB >> 10319137

Synthesis and antibacterial activity of new cephalosporins with lactonyloxyimino moiety.

K H Suh1, J W Park.   

Abstract

A series of 7-¿2-(2-aminothiazol-4-yl)-2-Z-(gamma-lacton-3-yl)oxyimin oacetamido¿ cephalosporins with various substituents at the 3-position in cephem nucleus were synthesized and evaluated microbiologically. The tested compounds showed potent activities but were somewhat less active than cefotaxime or cefixime against a wide variety of Gram-positive and Gram-negative bacteria.

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Year:  1994        PMID： 10319137     DOI： 10.1007/bf02974229

Source DB:  PubMed          Journal:  Arch Pharm Res        ISSN： 0253-6269            Impact factor:   4.946


  5 in total

1.  Experimental evaluation of HR756, a new cephalosporin derivative: pre-clinical study.

Authors:  R Heymès; A Lutz; E Schrinner
Journal:  Infection       Date:  1977       Impact factor: 3.553

2.  [Unexpected antibiotic properties of a cephalosporin].

Authors:  R Bucourt; R Heymès; A Lutz; L Pénasse; J Perronnet
Journal:  C R Acad Hebd Seances Acad Sci D       Date:  1977-05-09

3.  Synthesis and structure-activity relationships of 7 beta-[2-(2-aminothiazol-4-yl)acetamido]cephalosporin derivatives. IV. Synthesis of 2-(2-aminothiazol-4-yl)-2-methoxyiminoacetic acid derivatives and related compounds.

Authors:  M Ochiai; A Morimoto; Y Matsushita; T Okada
Journal:  J Antibiot (Tokyo)       Date:  1981-02       Impact factor: 2.649

4.  Studies on beta-lactam antibiotics. IX. Synthesis and biological activity of a new orally active cephalosporin, cefixime (FK027).

Authors:  H Yamanaka; T Chiba; K Kawabata; H Takasugi; T Masugi; T Takaya
Journal:  J Antibiot (Tokyo)       Date:  1985-12       Impact factor: 2.649

5.  GR 20263, a new broad-spectrum cephalosporin with anti-pseudomonal activity.

Authors:  C H O'Callaghan; P Acred; P B Harper; D M Ryan; S M Kirby; S M Harding
Journal:  Antimicrob Agents Chemother       Date:  1980-05       Impact factor: 5.191
  5 in total

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