| Literature DB >> 10319132 |
K A el-Bayouki1, W M Basyouni, S M el-Din, A G Habeeb.
Abstract
Reaction of 6-chloro-9-benzyl-8-(methylthio)purine 3 with primary amines afforded, the corresponding 6-(substitutedamino)purines 4a-g. The latter products when methylated with methyl iodide yielded smoothly N3-methyl purinium iodide salts 5a-f rather than the probable N1- and N7-derivatives. 9-Benzyl-3-methyl-6-(methylimino)-8-(methylthio)purine 8 was obtained upon treating the purinium iodide 5a with alkali. Most of the synthesized compounds were screened for their antitumor activity.Entities:
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Year: 1994 PMID： 10319132 DOI： 10.1007/bf02974224
Source DB: PubMed Journal: Arch Pharm Res ISSN： 0253-6269 Impact factor: 4.946