Literature DB >> 10319131

Effect of sodium taurodihydrofusidate on nasal drug delivery: differences in its concentration and penetrant molecular weight.

K Hosoya1, H Kubo, T Akutsu, H Natsume, K Sugibayashi, Y Morimoto.   

Abstract

The effect of sodium taurodihydrofusidate (STDHF) on drug permeation across nasal mucosa was studied in vitro using Ussing type diffusion chamber. Disodium cromoglicate (DSCG, M.W. 512.3) and fluorescein isothiocyanate-dextran (FD) of different molecular weights (M.W. 4400-71200) were used as model drugs. Permeation profiles of DSCG and FDs showed a typical pseudo steady-state curve with short lag time. The permeability coefficient of FD (M.W. 9400) sigmodially increased with increasing STDHF concentration. It also enhanced the DSCG permeation. Interestingly the enhancement efficacy was independent of molecular weight of penetrants.

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Year:  1994        PMID： 10319131     DOI： 10.1007/bf02974223

Source DB:  PubMed          Journal:  Arch Pharm Res        ISSN： 0253-6269            Impact factor:   4.946


  5 in total

1.  The structural barrier of absorptive mucosae: site difference of the permeability of fluorescein isothiocyanate-labelled dextran in rabbits.

Authors:  K Hosoya; H Kubo; H Natsume; K Sugibayashi; Y Morimoto; S Yamashita
Journal:  Biopharm Drug Dispos       Date:  1993-11       Impact factor: 1.627

2.  Site dependence of absorption-promoting actions of laureth-9, Na salicylate, Na2EDTA, and aprotinin on rectal, nasal, and buccal insulin delivery.

Authors:  B J Aungst; N J Rogers
Journal:  Pharm Res       Date:  1988-05       Impact factor: 4.200

3.  Effects of sodium taurodihydrofusidate on nasal absorption of insulin in sheep.

Authors:  J P Longenecker; A C Moses; J S Flier; R D Silver; M C Carey; E J Dubovi
Journal:  J Pharm Sci       Date:  1987-05       Impact factor: 3.534

4.  Studies on the promoting effects of medium chain fatty acid salts on the nasal absorption of insulin in rats.

Authors:  M Mishima; Y Wakita; M Nakano
Journal:  J Pharmacobiodyn       Date:  1987-11

5.  Nasal absorption of insulin: enhancement by hydrophobic bile salts.

Authors:  G S Gordon; A C Moses; R D Silver; J S Flier; M C Carey
Journal:  Proc Natl Acad Sci U S A       Date:  1985-11       Impact factor: 11.205
  5 in total
  1 in total

Review 1.  Absorption enhancers for nasal drug delivery.

Authors:  Stanley S Davis; Lisbeth Illum
Journal:  Clin Pharmacokinet       Date:  2003       Impact factor: 6.447
  1 in total

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