Literature DB >> 10319121

Nalidixic acid prodrugs: amides from amino acid ester and nalidixic acid.

A Taori, R Nema, D V Kohli, R K Uppadhyay.   

Abstract

Amides from amino acid ester and nalidixic acid were synthesized. The solubility characteristics and partition coefficient of the compounds were studied. The hydrolysis of the compounds was studied in the simulated gastric fluid and simulated intestinal fluid. Some compounds showed better antibacterial activity than nalidixic acid.

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Year:  1991        PMID: 10319121     DOI: 10.1007/bf02857814

Source DB:  PubMed          Journal:  Arch Pharm Res        ISSN: 0253-6269            Impact factor:   4.946


  2 in total

1.  Acetaminophen prodrugs. I. Synthesis, physicochemical properties, and analgesic activity.

Authors:  L W Dittert; H C Caldwell; H J Adams; G M Irwin; J V Swintosky
Journal:  J Pharm Sci       Date:  1968-05       Impact factor: 3.534

2.  Acetaminophen prodrugs. II. Effect of structure and enzyme source on enzymatic and nonenzymatic hydrolysis of carbonate esters.

Authors:  L W Dittert; G M Irwin; C W Chong; J V Swintosky
Journal:  J Pharm Sci       Date:  1968-05       Impact factor: 3.534

  2 in total

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