Literature DB >> 10319117

A synthetic study on cyclic phosphate derivatives of seconucleosides as potential antiviral agents (I). Synthesis of 3',5'-cyclic phosphates of 2'-substituted secouridines and secoribavirins.

K A Hong1, J W Yang, S J Chun, E Y Ha, J H Kim, M W Chun, W K Chung.   

Abstract

The synthetic study of 3',5-cyclic phosphates of 2'-substituted 2',3'-secouridines and 2',3'-secoribavirins toward development of new antiviral agents is described. These cyclic phosphates were synthesized from their respective 4-nitrophenyl 3',5'-cyclic phosphate triesters. These triesters were prepared from the corresponding 2'-azido and 2'-bromo 2',3'-seconucleosides.

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Year:  1991        PMID： 10319117     DOI： 10.1007/bf02857810

Source DB:  PubMed          Journal:  Arch Pharm Res        ISSN： 0253-6269            Impact factor:   4.946


  8 in total

1.  Selectivity of action of an antiherpetic agent, 9-(2-hydroxyethoxymethyl) guanine.

Authors:  G B Elion; P A Furman; J A Fyfe; P de Miranda; L Beauchamp; H J Schaeffer
Journal:  Proc Natl Acad Sci U S A       Date:  1977-12       Impact factor: 11.205

2.  Synthesis and antitumor and antiviral activities of a series of 1-beta-D-ribofuranosyl-5-halocytosine (5-halocytidine) cyclic 3',5'-monophosphates.

Authors:  J Beres; W G Bentrude; G Kruppa; P A McKernan; R K Robins
Journal:  J Med Chem       Date:  1985-04       Impact factor: 7.446

3.  Synthesis and antiviral acticity of some phosphates of the broad-spectrum antiviral nucleoside, 1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide (ribavirin).

Authors:  L B Allen; K H Boswell; T A Khwaja; R B Meyer; R W Sidwell; J T Witkowski; L F Christensen; R K Robins
Journal:  J Med Chem       Date:  1978-08       Impact factor: 7.446

4.  Synthesis and antiherpes virus activity of phosphate and phosphonate derivatives of 9-[(1,3-dihydroxy-2-propoxy)methyl]guanine.

Authors:  E J Prisbe; J C Martin; D P McGee; M F Barker; D F Smee; A E Duke; T R Matthews; J P Verheyden
Journal:  J Med Chem       Date:  1986-05       Impact factor: 7.446

5.  The preparation of 2'-deoxy-2'-fluoro-1',2'-seconucleosides as potential antiviral agents.

Authors:  P Vemishetti; R Saibaba; R P Panzica; E Abushanab
Journal:  J Med Chem       Date:  1990-02       Impact factor: 7.446

6.  Synthesis, structure, and reactivity of adenosine cyclic 3',5'-phosphate benzyl triesters.

Authors:  J Engels; E J Schlaeger
Journal:  J Med Chem       Date:  1977-07       Impact factor: 7.446

7.  Unique spectrum of activity of 9-[(1,3-dihydroxy-2-propoxy)methyl]-guanine against herpesviruses in vitro and its mode of action against herpes simplex virus type 1.

Authors:  Y C Cheng; E S Huang; J C Lin; E C Mar; J S Pagano; G E Dutschman; S P Grill
Journal:  Proc Natl Acad Sci U S A       Date:  1983-05       Impact factor: 11.205

8.  9-[(1,3-Dihydroxy-2-propoxy)methyl]guanine: a new potent and selective antiherpes agent.

Authors:  J C Martin; C A Dvorak; D F Smee; T R Matthews; J P Verheyden
Journal:  J Med Chem       Date:  1983-05       Impact factor: 7.446
  8 in total

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