Literature DB >> 1031371

Nicotine-11C: synthesis and distribution kinetics in animals.

M Mazière, D Comar, C Marazano, G Berger.   

Abstract

In order to study "in vivo" the distribution kinetics of (-)-nicotine in animals, this molecule was labeled with carbon-11. Two synthesis methods are described. Immediately after intravenous administration of (-)-nicotine-methyl-11C in rabbits the gamma-camera shows a strong radioactivity build-up in the brain and kidneys. The biological interest of this carbon-11 labeled molecule is discussed.

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Year:  1976        PMID： 1031371     DOI： 10.1007/BF00252173

Source DB:  PubMed          Journal:  Eur J Nucl Med        ISSN： 0340-6997


  12 in total

1.  DISPOSITION AND FATE OF (--)-COTININE-H3 IN THE MOUSE.

Authors:  E R BOWMAN; E HANSSON; L B TURNBULL; H MCKENNIS; C G SCHMITERLOEW
Journal:  J Pharmacol Exp Ther       Date:  1964-03       Impact factor: 4.030

2.  Physiological disposition and fate of C14-labelled nicotine in mice and rats.

Authors:  E HANSSON; C G SCHMITERLOW
Journal:  J Pharmacol Exp Ther       Date:  1962-07       Impact factor: 4.030

3.  Demethylation in the metabolism of (-)-nicotine in vivo.

Authors:  H MCKENNIS; E WADA; E R BOWMAN; L B TURNBULL
Journal:  Nature       Date:  1961-06-03       Impact factor: 49.962

4.  Studies of neurohypophyseal function in man.

Authors:  J F DINGMAN; K BENIRSCHKE; G W THORN
Journal:  Am J Med       Date:  1957-08       Impact factor: 4.965

5.  A nicotine test for the investigation of diabetes insipidus.

Authors:  A A G LEWIS; T M CHALMERS
Journal:  Clin Sci       Date:  1951-02       Impact factor: 6.124

6.  The stereospecificity of nicotine.

Authors:  R B Barlow; J T Hamilton
Journal:  Br J Pharmacol Chemother       Date:  1965-08

7.  Brain uptake of metabolites and drugs following carotid arterial injections.

Authors:  W H Oldendorf
Journal:  Trans Am Neurol Assoc       Date:  1971

8.  Pharmacological basis for the tobacco smoking habit.

Authors:  A K Armitage; G H Hall; C F Morrison
Journal:  Nature       Date:  1968-01-27       Impact factor: 49.962

9.  Synthesis of methyl iodide-11 C and formaldehyde-11 C.

Authors:  C Marazano; M Maziere; G Berger; D Comar
Journal:  Int J Appl Radiat Isot       Date:  1977 Jan-Feb

10.  The metabolism of [14C] nicotine in the cat.

Authors:  D M Turner
Journal:  Biochem J       Date:  1969-12       Impact factor: 3.857
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  5 in total

1.  Development and optimization of a novel automated loop method for production of [11C]nicotine.

Authors:  Arijit Ghosh; Karen Woolum; Michael V Knopp; Krishan Kumar
Journal:  Appl Radiat Isot       Date:  2018-05-30       Impact factor: 1.513

2.  Radioiodination of nicotine with specific activity high enough for mapping nicotinic acetylcholine receptors.

Authors:  I Kämpfer; D Sorger; R Schliebs; W Kärger; K Günther; K Schulze; W H Knapp
Journal:  Eur J Nucl Med       Date:  1996-02

3.  PET studies of the uptake of (S)- and (R)-[11C]nicotine in the human brain: difficulties in visualizing specific receptor binding in vivo.

Authors:  H Nybäck; C Halldin; A Ahlin; M Curvall; L Eriksson
Journal:  Psychopharmacology (Berl)       Date:  1994-06       Impact factor: 4.530

Review 4.  Development of radioligands with optimized imaging properties for quantification of nicotinic acetylcholine receptors by positron emission tomography.

Authors:  Andrew G Horti; Yongjun Gao; Hiroto Kuwabara; Robert F Dannals
Journal:  Life Sci       Date:  2009-03-18       Impact factor: 5.037

5.  Brain imaging of nicotinic receptors in Alzheimer's disease.

Authors:  Jin Wu; Masatomo Ishikawa; Jichun Zhang; Kenji Hashimoto
Journal:  Int J Alzheimers Dis       Date:  2010-12-28
  5 in total

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