Literature DB >> 103107

Phosphatidic acid releases calcium from a platelet membrane fraction in vitro.

J M Gerrard, A M Butler, D A Peterson, J G White.   

Abstract

A platelet membrane fraction which actively sequesters calcium in the presence of ATP was prepared and the influence of phosphatidic acid evaluated. At 10--60 micrograms/ml phosphatidic acid caused a concentration dependent release of calcium from the membrane fraction. The calcium was released from inside the vesicles, since release occurred in the presence of EGTA used to bind calcium outside the membrane vesicles. Aspirin failed to inhibit release of calcium by phosphatidic acid. Our results may explain, in part, the prostaglandin and thromboxane independent calcium release which occurs in response to certain aggregating agents. Thus, phosphatidic acid, or a metabolite, may have an important role intracellularly in platelets in promoting calcium movement.

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Year:  1978        PMID： 103107     DOI： 10.1016/0161-4630(78)90125-8

Source DB:  PubMed          Journal:  Prostaglandins Med        ISSN： 0161-4630


  12 in total

1.  A diacylglycerol kinase inhibitor, R59022, potentiates secretion by and aggregation of thrombin-stimulated human platelets.

Authors:  D L Nunn; S P Watson
Journal:  Biochem J       Date:  1987-05-01       Impact factor: 3.857

Review 2.  Organization and role of platelet membrane phospholipids as studied with purified phospholipases.

Authors:  H Chap; B Perret; G Mauco; M F Simon; L Douste-Blazy
Journal:  Agents Actions       Date:  1979-10

3.  Lysophosphatidic acids. Influence on platelet aggregation and intracellular calcium flux.

Authors:  J M Gerrard; S E Kindom; D A Peterson; J Peller; K E Krantz; J G White
Journal:  Am J Pathol       Date:  1979-08       Impact factor: 4.307

4.  Increased formation of phosphatidylinositol-4-phosphate in human platelets stimulated with lysophosphatidic acid.

Authors:  I Mani; D C Gaudette; B J Holub
Journal:  Lipids       Date:  1996-12       Impact factor: 1.880

5.  Lysophosphatidic acids. II. Interaction of the effects of adenosine diphosphate and lysophosphatidic acids in dog, rabbit, and human platelets.

Authors:  J M Gerrard; S E Kindom; D A Peterson; J G White
Journal:  Am J Pathol       Date:  1979-12       Impact factor: 4.307

6.  Stimulation of prostaglandin E2 synthesis by exogenous phospholipase A2 and C in rabbit kidney medulla slices.

Authors:  Y Fujimoto; N Akamatsu; A Hattori; T Fujita
Journal:  Biochem J       Date:  1984-02-15       Impact factor: 3.857

7.  Decanoyl lysophosphatidic acid induces platelet aggregation through an extracellular action. Evidence against a second messenger role for lysophosphatidic acid.

Authors:  S P Watson; R T McConnell; E G Lapetina
Journal:  Biochem J       Date:  1985-11-15       Impact factor: 3.857

8.  Platelet-activating factor stimulates metabolism of phosphoinositides in horse platelets: possible relationship to Ca2+ mobilization during stimulation.

Authors:  M M Billah; E G Lapetina
Journal:  Proc Natl Acad Sci U S A       Date:  1983-02       Impact factor: 11.205

9.  Accumulation of the inositol phosphates in thrombin-stimulated, washed rabbit platelets in the presence of lithium.

Authors:  J D Vickers; R L Kinlough-Rathbone; J F Mustard
Journal:  Biochem J       Date:  1984-12-01       Impact factor: 3.857

10.  Lysophosphatidic acids: III. Enhancement of neutrophil chemotaxis.

Authors:  J M Gerrard; C C Clawson; J G White
Journal:  Am J Pathol       Date:  1980-09       Impact factor: 4.307
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