Indocyanine green plasma clearance in normal human males and females.

The plasma clearance of indocyanine green (Cardio-Green, 0.5 mg/kg body weight) was studied in a total of 352 plasma samples from 7 male and 8 female healthy volunteers, and total bilirubinaemia in 6 males and 6 females. Statistical analysis (linear regression, SAAM programmes by BERMAN and WEISS [2],t-test. F-test and rank correlation) disclosed a significantly higher plasma disappearance rate of indocyanine green and significantly lower total bilirubinaemia in females than in males with a statistically almost significant negative correlation of both phenomena. A better excretion of indocyanine green from liver to bile in males though statistically significant could be an artefact caused e.g. by a not quite significant abnormally of the calibration straight line of the dye.