Literature DB >> 1030181

Characterization of the biochemical mechanism of action of alpha-(N)-heterocyclic carboxaldehyde thiosemicarbazones.

A C Sartorelli, K C Agrawal, A S Tsiftsoglou, E C Moore.   

Abstract

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Year:  1976        PMID： 1030181     DOI： 10.1016/0065-2571(77)90012-7

Source DB:  PubMed          Journal:  Adv Enzyme Regul        ISSN： 0065-2571


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  10 in total

1.  A copper chelate of thiosemicarbazone NSC 689534 induces oxidative/ER stress and inhibits tumor growth in vitro and in vivo.

Authors:  Chad N Hancock; Luke H Stockwin; Bingnan Han; Raymond D Divelbiss; Jung Ho Jun; Sanjay V Malhotra; Melinda G Hollingshead; Dianne L Newton
Journal:  Free Radic Biol Med       Date:  2010-11-04       Impact factor: 7.376

2.  Experimental combination chemotherapy with thymidylate synthetase and ribonucleotide reductase inhibitors.

Authors:  S Kobayashi; T Hoshino; D V Santi
Journal:  Pharm Res       Date:  1984-07       Impact factor: 4.200

3.  Triapine disrupts CtIP-mediated homologous recombination repair and sensitizes ovarian cancer cells to PARP and topoisomerase inhibitors.

Authors:  Z Ping Lin; Elena S Ratner; Margaret E Whicker; Yashang Lee; Alan C Sartorelli
Journal:  Mol Cancer Res       Date:  2014-01-10       Impact factor: 5.852

4.  Copper-Binding Small Molecule Induces Oxidative Stress and Cell-Cycle Arrest in Glioblastoma-Patient-Derived Cells.

Authors:  Kenichi Shimada; Eduard Reznik; Michael E Stokes; Lakshmi Krishnamoorthy; Pieter H Bos; Yuyu Song; Christine E Quartararo; Nen C Pagano; Darren R Carpizo; Ana C deCarvalho; Donald C Lo; Brent R Stockwell
Journal:  Cell Chem Biol       Date:  2018-03-22       Impact factor: 8.116

5.  Distinct mechanisms of cell-kill by triapine and its terminally dimethylated derivative Dp44mT due to a loss or gain of activity of their copper(II) complexes.

Authors:  Kimiko Ishiguro; Z Ping Lin; Philip G Penketh; Krishnamurthy Shyam; Rui Zhu; Raymond P Baumann; Yong-Lian Zhu; Alan C Sartorelli; Thomas J Rutherford; Elena S Ratner
Journal:  Biochem Pharmacol       Date:  2014-08-15       Impact factor: 5.858

6.  Identification of the di-pyridyl ketone isonicotinoyl hydrazone (PKIH) analogues as potent iron chelators and anti-tumour agents.

Authors:  Erika M Becker; David B Lovejoy; Judith M Greer; Ralph Watts; Des R Richardson
Journal:  Br J Pharmacol       Date:  2003-03       Impact factor: 8.739

Review 7.  Antifungal and antitumor activity of heterocyclic thiosemicarbazones and their metal complexes: current status.

Authors:  A E Liberta; D X West
Journal:  Biometals       Date:  1992       Impact factor: 2.949

8.  Ribonucleotide reductase inhibition by metal complexes of Triapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone): a combined experimental and theoretical study.

Authors:  Ana Popović-Bijelić; Christian R Kowol; Maria E S Lind; Jinghui Luo; Fahmi Himo; Eva A Enyedy; Vladimir B Arion; Astrid Gräslund
Journal:  J Inorg Biochem       Date:  2011-07-31       Impact factor: 4.155

9.  Triapine potentiates platinum-based combination therapy by disruption of homologous recombination repair.

Authors:  Elena S Ratner; Yong-Lian Zhu; Philip G Penketh; Julie Berenblum; Margaret E Whicker; Pamela H Huang; Yashang Lee; Kimiko Ishiguro; Rui Zhu; Alan C Sartorelli; Z Ping Lin
Journal:  Br J Cancer       Date:  2016-03-10       Impact factor: 7.640

Review 10.  Targeting Cyclin-Dependent Kinases for Treatment of Gynecologic Cancers.

Authors:  Z Ping Lin; Yong-Lian Zhu; Elena S Ratner
Journal:  Front Oncol       Date:  2018-08-08       Impact factor: 6.244
  10 in total

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