Literature DB >> 1028952

Effect of ventromedial and dorsomedial hypothalamic lesions on circadian corticosterone rhythms.

L L Bellinger, L L Bernardis, V E Mendel.   

Abstract

Weanling rats received bilateral electrolytic lesions in the dorsomedial (DMH) or ventromedial (VMH) hypothalamic areas destroying primarily the dorsomedial (DMN) or ventromedial (VMN) hypothalamic nuclei. Sham-operated rats served as controls. Lesions in the VMN and DMN, both of which have previously been shown to disrupt normal diurnal feeding rhythms, were also observed to disrupt normal plasma corticosterone rhythms in the present study. The a.m. values of plasma corticosterone in the DMN-lesioned rats were higher than the sham-operated controls. In the p.m., the values of both VMN- and DMN-lesioned rats were lower than those of the controls but unchanged in comparison to their own a.m. concentrations. This disruption of the normal diurnal plasma corticosterone rhythm persisted for at least 9 post-operative weeks.

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Year:  1976        PMID： 1028952     DOI： 10.1159/000122628

Source DB:  PubMed          Journal:  Neuroendocrinology        ISSN： 0028-3835            Impact factor:   4.914


  7 in total

1.  Contrasting effects of ibotenate lesions of the paraventricular nucleus and subparaventricular zone on sleep-wake cycle and temperature regulation.

Authors:  J Lu; Y H Zhang; T C Chou; S E Gaus; J K Elmquist; P Shiromani; C B Saper
Journal:  J Neurosci       Date:  2001-07-01       Impact factor: 6.167

2.  Physiological glucocorticoid levels regulate glutamine and insulin-mediated glucose metabolism in skeletal muscle of the rat. Studies with RU 486 (mifepristone).

Authors:  B Leighton; M Parry-Billings; G Dimitriadis; J Bond; E A Newsholme; C DaCosta; E A Foot
Journal:  Biochem J       Date:  1991-02-15       Impact factor: 3.857

3.  The hypothalamic ventromedial nuclei couple activity in the hypothalamo-pituitary-adrenal axis to the morning fed or fasted state.

Authors:  S Choi; C Horsley; S Aguila; M F Dallman
Journal:  J Neurosci       Date:  1996-12-15       Impact factor: 6.167

4.  Leptin activates distinct projections from the dorsomedial and ventromedial hypothalamic nuclei.

Authors:  J K Elmquist; R S Ahima; C F Elias; J S Flier; C B Saper
Journal:  Proc Natl Acad Sci U S A       Date:  1998-01-20       Impact factor: 11.205

Review 5.  Sex differences in circadian timing systems: implications for disease.

Authors:  Matthew Bailey; Rae Silver
Journal:  Front Neuroendocrinol       Date:  2013-11-25       Impact factor: 8.606

Review 6.  Functional organization of neuronal and humoral signals regulating feeding behavior.

Authors:  Gary J Schwartz; Lori M Zeltser
Journal:  Annu Rev Nutr       Date:  2013-04-29       Impact factor: 11.848

7.  Inhibitory function of the dorsomedial hypothalamic nucleus on the hypothalamic-pituitary-adrenal axis response to an emotional stressor but not immune challenge.

Authors:  K Ebner; P Muigg; N Singewald
Journal:  J Neuroendocrinol       Date:  2013-01       Impact factor: 3.627
  7 in total

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