Literature DB >> 1027713

Evidence for the genetic control of antibody affinity from breeding studies with inbred mouse strains producing high and low affinity antibody.

M W Steward, R E Petty.   

Abstract

The amount (Abt) and relative affinity (KR) of antibody produced in response to protein antigens injected in saline has been measured in the parents, F1 hybrids and backcross offspring of inbred mice which produce high and low KR antibody to these antigens. The results obtained support the view that antibody affinity is under polygenic control. Furthermore, strain related variation in Abt is independent of KR and the breeding experiments indicate that these two parameters are under independent genetic control.

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Year:  1976        PMID： 1027713      PMCID： PMC1445070     

Source DB:  PubMed          Journal:  Immunology        ISSN： 0019-2805            Impact factor:   7.397


  20 in total

1.  Low affinity antibody production in mice - a form of immunological tolerance?

Authors:  M W Steward; S E Gaze; R E Petty
Journal:  Eur J Immunol       Date:  1974-11       Impact factor: 5.532

2.  Depletion of long-lived lymphocytes in old New Zealand black mice.

Authors:  A M Denman; E J Denman
Journal:  Clin Exp Immunol       Date:  1970-04       Impact factor: 4.330

Review 3.  The function of macrophages in the immune response.

Authors:  E R Unanue; J C Cerottini
Journal:  Semin Hematol       Date:  1970-04       Impact factor: 3.851

4.  The antigen-binding characteristics of antibody pools of different relative affinity.

Authors:  M W Steward; R E Petty
Journal:  Immunology       Date:  1972-12       Impact factor: 7.397

5.  The heterogeneity of antibody affinity in inbred mice and its possible immunopathologic significance.

Authors:  R E Petty; M W Steward; J F Soothill
Journal:  Clin Exp Immunol       Date:  1972-10       Impact factor: 4.330

6.  Differences in immune elimination in inbred mice. The role of low affinity antibody.

Authors:  J H Alpers; M W Steward; J F Soothill
Journal:  Clin Exp Immunol       Date:  1972-09       Impact factor: 4.330

7.  The use of ammonium sulphate globulin precipitation for determination of affinity of anti-protein antibodies in mouse serum.

Authors:  M W Steward; R E Petty
Journal:  Immunology       Date:  1972-05       Impact factor: 7.397

8.  Effect of thymus-derived lymphocytes on amount and affinity of anti-hapten antibody.

Authors:  R K Gershon; W E Paul
Journal:  J Immunol       Date:  1971-03       Impact factor: 5.422

9.  The immunopathological significance of the heterogeneity of antibody affinity.

Authors:  J F Soothill; M W Steward
Journal:  Clin Exp Immunol       Date:  1971-08       Impact factor: 4.330

10.  The role of low affinity antibody in immune complex disease. The quantity of anti-DNA antibodies in NZB/W F1 hybrid mice.

Authors:  M W Steward; F E Katz; N J West
Journal:  Clin Exp Immunol       Date:  1975-07       Impact factor: 4.330
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  10 in total

1.  Chronic immune complex disease in mice: the role of antibody affinity.

Authors:  M W Steward
Journal:  Clin Exp Immunol       Date:  1979-12       Impact factor: 4.330

Review 2.  Antibody affinity: immunogenetic aspects and relationship to immune complex disease.

Authors:  M W Steward
Journal:  J Clin Pathol Suppl (R Coll Pathol)       Date:  1979

3.  Antibody affinity and clearance function studies in high and low antibody affinity mice. The effect of protein deficiency.

Authors:  M C Reinhardt; M W Steward
Journal:  Immunology       Date:  1979-12       Impact factor: 7.397

4.  The genetic control of antibody affinity. Evidence from breeding studies with mice selectively bred for either high or low affinity antibody production.

Authors:  M W Steward; M C Reinhardt; N A Staines
Journal:  Immunology       Date:  1979-07       Impact factor: 7.397

5.  No evidence of abnormal regulation of antibody response to coxsackievirus B4 antigen in prediabetic children.

Authors:  L Heino; M Lönnrot; M Knip; A Kupila; S Erkkilä; A Toivonen; P Vähäsalo; J Ilonen; O Simell; H Hyöty
Journal:  Clin Exp Immunol       Date:  2001-12       Impact factor: 4.330

6.  DNA binding activity of serum from patients with systemic lupus erythematosus.

Authors:  J F Halsey; W A Woolery; S Oleinick; M B Kahaleh; E C Leroy
Journal:  Clin Exp Immunol       Date:  1979-03       Impact factor: 4.330

7.  Antibody avidity in swine lymphocyte antigen-defined miniature pigs.

Authors:  G D Appleyard; B A Mallard; B W Kennedy; B N Wilkie
Journal:  Can J Vet Res       Date:  1992-10       Impact factor: 1.310

8.  The induction of chronic antigen-antibody complex disease in selectively bred mice producing either high or low affinity antibody to protein antigens.

Authors:  M E Devey; M W Steward
Journal:  Immunology       Date:  1980-10       Impact factor: 7.397

9.  Poliovirus antibody titres, relative affinity, and neutralising capacity in maternal milk.

Authors:  S Zaman; B Carlsson; A Morikawa; S Jeansson; I Narayanan; K Thiringer; F Jalil; L A Hanson
Journal:  Arch Dis Child       Date:  1993-02       Impact factor: 3.791

10.  The effect of protein deficiency on the development of chronic antigen-antibody complex disease in mice.

Authors:  M C Reinhardt; M Devey; M Collins; B Gregory; M W Steward
Journal:  Clin Exp Immunol       Date:  1981-06       Impact factor: 4.330
  10 in total

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