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Literature DB >> 1025156

Concanavalin A induces microtubule assembly and specific granule discharge in human polymorphonuclear leukocytes.

S Hoffstein, R Soberman, I Goldstein, G Weissmann.

Abstract

Human neutrophils stimulated by concanavalin A (Con A, 100 microng/ml) contained markedly enhanced numbers of microtubules and discharged peroxidase-negative (specific) but not peroxidase-position (azurophile) granules. Release of lysozyme from specific granules was dose and time dependent, could be inhibitied by alpha-methyl-D-mannoside, and enhanced by cytochalasin B. Many microtubules were associated with internalized plasma membrane bearing Con A binding sites.

Entities: Chemical Species

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Year: 1976 PMID： 1025156 PMCID： PMC2109658 DOI： 10.1083/jcb.68.3.781

Source DB: PubMed Journal: J Cell Biol ISSN： 0021-9525 Impact factor: 10.539

18 in total

1. Metalloenzymes and myocardial infarction. II. Malic and lactic dehydrogenase activities and zinc concentrations in serum.

Authors: D D ULMER; B L VALLEE; W E WACKER
Journal: N Engl J Med Date: 1956-09-06 Impact factor: 91.245

Review 2. Reciprocal effects of cAMP and cGMP on microtubule-dependent release of lysosomal enzymes.

Authors: G Weissmann; I Goldstein; S Hoffstein; P K Tsung
Journal: Ann N Y Acad Sci Date: 1975-06-30 Impact factor: 5.691

3. The inhibition of phagocytosis and facilitation of exocytosis in rabbit polymorphonuclear leukocytes by cytochalasin B.

Authors: P Davies; R I Fox; M Polyzonis; A C Allison; A D Haswell
Journal: Lab Invest Date: 1973-01 Impact factor: 5.662

Review 4. Microtubules.

Authors: J B Olmsted; G G Borisy
Journal: Annu Rev Biochem Date: 1973 Impact factor: 23.643

5. Mechanisms of lysosomal enzyme release from human leukocytes: microtubule assembly and membrane fusion induced by a component of complement.

Authors: I Goldstein; S Hoffstein; J Gallin; G Weissmann
Journal: Proc Natl Acad Sci U S A Date: 1973-10 Impact factor: 11.205

6. Mechanisms of lysosomal enzyme release from human leucocytes. III. Quantitative morphologic evidence for an effect of cyclic nucleotides and colchicine on degranulation.

Authors: S Hoffstein; R B Zurier; G Weissmann
Journal: Clin Immunol Immunopathol Date: 1974-11

7. Effects of phagocytosis and colchicine on the distribution of lectin-binding sites on cell surfaces.

Authors: J M Oliver; T E Ukena; R D Berlin
Journal: Proc Natl Acad Sci U S A Date: 1974-02 Impact factor: 11.205

8. Selective labilization of specific granules in polymorphonuclear leukocytes by phorbol myristate acetate.

Authors: J G White; R D Estensen
Journal: Am J Pathol Date: 1974-04 Impact factor: 4.307

9. Mechanisms of lysosomal enzyme release from human leukocytes. II. Effects of cAMP and cGMP, autonomic agonists, and agents which affect microtubule function.

Authors: R B Zurier; G Weissmann; S Hoffstein; S Kammerman; H H Tai
Journal: J Clin Invest Date: 1974-01 Impact factor: 14.808

10. The development of neutrophilic polymorphonuclear leukocytes in human bone marrow.

Authors: D F Bainton; J L Ullyot; M G Farquhar
Journal: J Exp Med Date: 1971-10-01 Impact factor: 14.307

44 in total

1. Collagenase is a component of the specific granules of human neutrophil leucocytes.

Authors: G Murphy; J J Reynolds; U Bretz; M Baggiolini
Journal: Biochem J Date: 1977-01-15 Impact factor: 3.857

2. Role of microtubules in low density lipoprotein processing by cultured cells.

Authors: R E Ostlund; B Pfleger; G Schonfeld
Journal: J Clin Invest Date: 1979-01 Impact factor: 14.808

Review 3. Cell biology of leukocyte abnormalities--membrane and cytoskeletal function in normal and defective cells. A review.

Authors: J M Oliver
Journal: Am J Pathol Date: 1978-10 Impact factor: 4.307

Review 4. The polymorphonuclear leukocyte.

Authors: M Baggiolini; U Bretz; B Dewald; M E Feigenson
Journal: Agents Actions Date: 1978-01

5. The differentiation of monocytes into macrophages, epithelioid cells, and multinucleated giant cells in subcutaneous granulomas. I. Fine structure.

Authors: H J van der Rhee; C P van der Burgh-de Winter; W T Daems
Journal: Cell Tissue Res Date: 1979-04-12 Impact factor: 5.249