Neoplastic complications of neurofibromatosis.

Neurofibromatosis associated with secondary neoplasms is discussed. Neurosarcomas are the most common and most malignant secondary tumors in neurofibromatosis. Any sudden growth in a peripheral tumor in this disease should alert the physician to the possibility of malignant change and the need for biopsy. Only by early diagnosis and adequate excision can some of these patients be saved.