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Literature DB >> 1024824

Why do Tc-99m chelates work for cholescintigraphy?

Abstract

There are four structural requirements for substances that are excreted by the liver: 1. Their molecular weight is between 300 and 1,000. 2. They are organic anions. 3. They contain at least two ring systems in the molecule. 4. They are bound to serum albumin. All the Tc-99m chelates suggested for cholescintigraphy fulfill these requirements. For the first time a rational for their efficacy is provided.

Entities: Chemical Gene

Mesh：

Substances：

Year: 1976 PMID： 1024824 DOI： 10.1007/BF00257959

Source DB: PubMed Journal: Eur J Nucl Med ISSN： 0340-6997

9 in total

1. THE INFLUENCE OF ENTEROHEPATIC CIRCULATION ON TOXICITY OF DRUGS.

Authors: R T WILLIAMS; P MILLBURN; R L SMITH
Journal: Ann N Y Acad Sci Date: 1965-03-12 Impact factor: 5.691

2. The intrahepatic conjugation of sulfobromophthalein and glutathione in the dog.

Authors: N B JAVITT; H O WHEELER; K J BAKER; O L RAMOS; S E BRADLEY
Journal: J Clin Invest Date: 1960-10 Impact factor: 14.808

3. Metabolism of tetracycline in the rat and the dog.

Authors: R G KELLY; D A BUYSKE
Journal: J Pharmacol Exp Ther Date: 1960-10 Impact factor: 4.030

4. Mechanisms of bile secretion.

Authors: R W BRAUER
Journal: J Am Med Assoc Date: 1959-03-28

5. Technetium 99m-pyridoxylideneglutamate: a new hepatobiliary radiopharmaceutical. I. Experimental aspects.

Authors: R J Baker; J C Bellen; P M Ronai
Journal: J Nucl Med Date: 1975-08 Impact factor: 10.057

6. A 99mTc-labeled replacement for 131-I-rose bengal in liver and biliary tract studies.

Authors: T H Lin; A Khentigan; H S Winchell
Journal: J Nucl Med Date: 1974-07 Impact factor: 10.057

7. 123I-iodo-bromsulphalein as a liver and biliary scanning agent.

Authors: M L Goris
Journal: J Nucl Med Date: 1973-11 Impact factor: 10.057

8. 99MTc-tetracycline as a kidney and gallbladder imaging agent.

Authors: C P Fliegel; M K Dewanjee; L B Holman; M A Davis; S Treves
Journal: Radiology Date: 1974-02 Impact factor: 11.105

9. Technetium-99m-pyridoxylideneglutamate: a new hepatobiliary radiopharmaceutical. II. Clinical aspects.

Authors: P M Ronai; R J Baker; J C Bellen; P J Collins; P J Anderson; H Lander
Journal: J Nucl Med Date: 1975-08 Impact factor: 10.057

9 in total

5 in total

Why do Tc-99m chelates work for cholescintigraphy?

1. THE INFLUENCE OF ENTEROHEPATIC CIRCULATION ON TOXICITY OF DRUGS.

2. The intrahepatic conjugation of sulfobromophthalein and glutathione in the dog.

3. Metabolism of tetracycline in the rat and the dog.

4. Mechanisms of bile secretion.

5. Technetium 99m-pyridoxylideneglutamate: a new hepatobiliary radiopharmaceutical. I. Experimental aspects.

6. A 99mTc-labeled replacement for 131-I-rose bengal in liver and biliary tract studies.

7. 123I-iodo-bromsulphalein as a liver and biliary scanning agent.

8. 99MTc-tetracycline as a kidney and gallbladder imaging agent.

9. Technetium-99m-pyridoxylideneglutamate: a new hepatobiliary radiopharmaceutical. II. Clinical aspects.

1. What does protein binding of radiopharmaceuticals mean exactly?

2. The hepatic excretion of 131I-rose bengal and 99mTc-IDA derivatives in Rotor's syndrome.

3. 99mTc-diethyl-HIDA: a contribution to the study of its structure.

Review 4. Role of 99mTc-IDA cholescintigraphy in evaluating biliary tract disorders.

5. The plasma protein binding of HIDA.