Literature DB >> 102431

Isolation, structural studies and chemical synthesis of a 'palmitone lipid' from Corynebacterium diphtheriae.

A Ahibo-Coffy, H Aurelle, C Lacave, J C Prome, G Puzo, A Savagnac.   

Abstract

The isolation of a 'palmitone lipid' from Corynebacterium diphtheriae is described. The use of a temporary hydrophobic protecting group allows the obtaining of the lipid in free and pure form. Structural studies by chemical degradation and mass spectrometry allow one to propose structure Ic for this compound, namely 6-(2-tetradecyl 3-keto octadecanoyl)-alpha-D-trehalose. This structure was confirmed by chemical synthesis.

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Year:  1978        PMID: 102431     DOI: 10.1016/0009-3084(78)90025-7

Source DB:  PubMed          Journal:  Chem Phys Lipids        ISSN: 0009-3084            Impact factor:   3.329


  2 in total

1.  An Antibacterial β-Lactone Kills Mycobacterium tuberculosis by Disrupting Mycolic Acid Biosynthesis.

Authors:  Johannes Lehmann; Tan-Yun Cheng; Anup Aggarwal; Annie S Park; Evelyn Zeiler; Ravikiran M Raju; Tatos Akopian; Olga Kandror; James C Sacchettini; D Branch Moody; Eric J Rubin; Stephan A Sieber
Journal:  Angew Chem Int Ed Engl       Date:  2017-12-05       Impact factor: 15.336

2.  The Pks13/FadD32 crosstalk for the biosynthesis of mycolic acids in Mycobacterium tuberculosis.

Authors:  Sabine Gavalda; Mathieu Léger; Benoît van der Rest; Alexandre Stella; Fabienne Bardou; Henri Montrozier; Christian Chalut; Odile Burlet-Schiltz; Hedia Marrakchi; Mamadou Daffé; Annaïk Quémard
Journal:  J Biol Chem       Date:  2009-05-12       Impact factor: 5.157

  2 in total

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