| Literature DB >> 10234860 |
G Topçu1, R Erenler, O Cakmak, C B Johansson, C Celik, H B Chai, J M Pezzuto.
Abstract
From the hexane extract of berries of Juniperus excelsa, one new and four known diterpenes were isolated besides a known sesquiterpene. The structures of the known diterpenes were identified as isopimaric, isocommunic, (-)ent-trans communic and sandracopimaric acids, along with the sesquiterpene 4a-hydroxycedrol and the new compound which was elucidated as 3 alpha-acetoxylabda-8(17),13(16),14-trien-19-oic acid (juniperexcelsic acid). Cytotoxic activity of the hexane extract was investigated against a panel of cell line and found highly active against LNCaP, KB-V (+VLB) and KB-V (-VLB) cell lines. Furthermore, the hexane and methanol extracts, and the new compound were found to be moderately active against Mycobacterium tuberculosis.Entities:
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Year: 1999 PMID： 10234860 DOI： 10.1016/s0031-9422(98)00675-x
Source DB: PubMed Journal: Phytochemistry ISSN： 0031-9422 Impact factor: 4.072