Literature DB >> 10233989

Infection of primary cultures of human Kupffer cells by Dengue virus: no viral progeny synthesis, but cytokine production is evident.

P Marianneau1, A M Steffan, C Royer, M T Drouet, D Jaeck, A Kirn, V Deubel.   

Abstract

We investigated the ability of dengue virus to invade human primary Kupffer cells and to complete its life cycle. The virus effectively penetrated Kupffer cells, but the infection did not result in any viral progeny. Dengue virus-replicating Kupffer cells underwent apoptosis and were cleared by phagocytosis. Infected Kupffer cells produced soluble mediators that could intervene in dengue virus pathogenesis.

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Year:  1999        PMID: 10233989      PMCID: PMC112571     

Source DB:  PubMed          Journal:  J Virol        ISSN: 0022-538X            Impact factor:   5.103


  27 in total

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  35 in total

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Authors:  M S Diamond; D Edgil; T G Roberts; B Lu; E Harris
Journal:  J Virol       Date:  2000-09       Impact factor: 5.103

Review 2.  Molecular targets for flavivirus drug discovery.

Authors:  Aruna Sampath; R Padmanabhan
Journal:  Antiviral Res       Date:  2008-09-15       Impact factor: 5.970

3.  Characterization of dengue virus 2 growth in megakaryocyte-erythrocyte progenitor cells.

Authors:  Kristina B Clark; Hui-Mien Hsiao; Leda Bassit; James E Crowe; Raymond F Schinazi; Guey Chuen Perng; Francois Villinger
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Journal:  World J Clin Cases       Date:  2015-02-16       Impact factor: 1.337

5.  A single amino acid substitution in the envelope protein of chimeric yellow fever-dengue 1 vaccine virus reduces neurovirulence for suckling mice and viremia/viscerotropism for monkeys.

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Journal:  J Virol       Date:  2004-09       Impact factor: 5.103

6.  Activation of terminally differentiated human monocytes/macrophages by dengue virus: productive infection, hierarchical production of innate cytokines and chemokines, and the synergistic effect of lipopolysaccharide.

Authors:  Yun-Chi Chen; Sheng-Yuan Wang
Journal:  J Virol       Date:  2002-10       Impact factor: 5.103

7.  An external loop region of domain III of dengue virus type 2 envelope protein is involved in serotype-specific binding to mosquito but not mammalian cells.

Authors:  Jan-Jong Hung; Meng-Ti Hsieh; Ming-Jer Young; Chuan-Liang Kao; Chwan-Chuen King; Wen Chang
Journal:  J Virol       Date:  2004-01       Impact factor: 5.103

8.  Primary human splenic macrophages, but not T or B cells, are the principal target cells for dengue virus infection in vitro.

Authors:  Shanley Blackley; Zhihua Kou; Huiyuan Chen; Matthew Quinn; Robert C Rose; Jacob J Schlesinger; Myra Coppage; Xia Jin
Journal:  J Virol       Date:  2007-10-10       Impact factor: 5.103

9.  Viral replication and paracrine effects result in distinct, functional responses of dendritic cells following infection with dengue 2 virus.

Authors:  Zachary D Nightingale; Chinmay Patkar; Alan L Rothman
Journal:  J Leukoc Biol       Date:  2008-07-23       Impact factor: 4.962

10.  Dengue virus infection induces upregulation of GRP78, which acts to chaperone viral antigen production.

Authors:  S Wati; M-L Soo; P Zilm; P Li; A W Paton; C J Burrell; M Beard; J M Carr
Journal:  J Virol       Date:  2009-09-30       Impact factor: 5.103

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