Literature DB >> 10232074

Structure-activity studies: in vitro antileishmanial and antimalarial activities of anthraquinones from Morinda lucida.

A A Sittie, E Lemmich, C E Olsen, L Hviid, A Kharazmi, F K Nkrumah, S B Christensen.   

Abstract

Anthraquinones have been isolated by bioassay-guided fractionation from Morinda lucida. Structure-activity studies show that an aldehyde group at C-2 and a phenolic hydroxy group at C-3 enhance the activity of the anthraquinones against the growth of Plasmodium falciparum and promastigotes of Leishmania major in vitro.

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Year:  1999        PMID： 10232074     DOI： 10.1055/s-2006-960473

Source DB:  PubMed          Journal:  Planta Med        ISSN： 0032-0943            Impact factor:   3.352


  12 in total

1.  From Drug Screening to Target Deconvolution: a Target-Based Drug Discovery Pipeline Using Leishmania Casein Kinase 1 Isoform 2 To Identify Compounds with Antileishmanial Activity.

Authors:  Emilie Durieu; Eric Prina; Olivier Leclercq; Nassima Oumata; Nicolas Gaboriaud-Kolar; Konstantina Vougogiannopoulou; Nathalie Aulner; Audrey Defontaine; Joo Hwan No; Sandrine Ruchaud; Alexios-Leandros Skaltsounis; Hervé Galons; Gerald F Späth; Laurent Meijer; Najma Rachidi
Journal:  Antimicrob Agents Chemother       Date:  2016-04-22       Impact factor: 5.191

2.  Methyl 5,7-dihydr-oxy-2,2,9-trimethyl-6,11-dioxo-6,11-dihydro-2H-anthra[2,3-b]pyran-8-carboxyl-ate.

Authors:  Diderot Noungoue Tchamo; Lydia Brelot; Cyril Antheaume; Silvère Ngouela; Annelise Lobstein
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2008-11-22

3.  Hydroxylated anthraquinones produced by Geosmithia species.

Authors:  E Stodůlková; M Kolarík; Z Kresinová; M Kuzma; M Sulc; P Man; P Novák; P Marsík; P Landa; J Olsovská; M Chudícková; S Pazoutová; J Cerný; J Bella; M Flieger
Journal:  Folia Microbiol (Praha)       Date:  2009-08-02       Impact factor: 2.099

4.  2-Formyl-3-hydr-oxy-9,10-anthroquinone.

Authors:  Nor Hadiani Ismail; Che Puteh Osman; Khalijah Awang; Sri Nurestri Abdul Malek; Seik Weng Ng
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2008-10-22

5.  Antiplasmodial potential and quantification of aloin and aloe-emodin in Aloe vera collected from different climatic regions of India.

Authors:  Sandeep Kumar; Manila Yadav; Amita Yadav; Pooja Rohilla; Jaya Parkash Yadav
Journal:  BMC Complement Altern Med       Date:  2017-07-17       Impact factor: 3.659

6.  Microbial Synthesis of Non-Natural Anthraquinone Glucosides Displaying Superior Antiproliferative Properties.

Authors:  Trang Thi Huyen Nguyen; Ramesh Prasad Pandey; Prakash Parajuli; Jang Mi Han; Hye Jin Jung; Yong Il Park; Jae Kyung Sohng
Journal:  Molecules       Date:  2018-08-28       Impact factor: 4.411

7.  In-silico investigation of antitrypanosomal phytochemicals from Nigerian medicinal plants.

Authors:  William N Setzer; Ifedayo V Ogungbe
Journal:  PLoS Negl Trop Dis       Date:  2012-07-24

8.  In vitro anti-Onchocerca ochengi activities of extracts and chromatographic fractions of Craterispermum laurinum and Morinda lucida.

Authors:  Moses Samje; Jonathan Metuge; James Mbah; Brice Nguesson; Fidelis Cho-Ngwa
Journal:  BMC Complement Altern Med       Date:  2014-09-01       Impact factor: 3.659

9.  Antitrypanosomal Activities and Mechanisms of Action of Novel Tetracyclic Iridoids from Morinda lucida Benth.

Authors:  Kofi D Kwofie; Nguyen Huu Tung; Mitsuko Suzuki-Ohashi; Michael Amoa-Bosompem; Richard Adegle; Maxwell M Sakyiamah; Frederick Ayertey; Kofi Baffour-Awuah Owusu; Isaac Tuffour; Philip Atchoglo; Kwadwo K Frempong; William K Anyan; Takuhiro Uto; Osamu Morinaga; Taizo Yamashita; Frederic Aboagye; Alfred A Appiah; Regina Appiah-Opong; Alexander K Nyarko; Yasuchika Yamaguchi; Dominic Edoh; Kwadwo A Koram; Shoji Yamaoka; Daniel A Boakye; Nobuo Ohta; Yukihiro Shoyama; Irene Ayi
Journal:  Antimicrob Agents Chemother       Date:  2016-05-23       Impact factor: 5.191

10.  Ultrastructural Changes and Death of Leishmania infantum Promastigotes Induced by Morinda citrifolia Linn. Fruit (Noni) Juice Treatment.

Authors:  Fernando Almeida-Souza; Noemi Nosomi Taniwaki; Ana Cláudia Fernandes Amaral; Celeste da Silva Freitas de Souza; Kátia da Silva Calabrese; Ana Lúcia Abreu-Silva
Journal:  Evid Based Complement Alternat Med       Date:  2016-05-22       Impact factor: 2.629
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