Synthetic routes to lipidic diamines and amino alcohols: a class of potential antiinflammatory agents.

Simple and efficient methods for the synthesis of lipidic amino alcohols and diamines are described in this paper. Lipidic 2-amino alcohols and 1,3-diamines can be synthesized starting from synthetic lipidic alpha-amino acids. Alternatively, commercially available lipidic 1,2-diols may be used as starting material for the synthesis of 2-amino alcohols. Initial experiments on the in vivo antiinflammatory activity of the compounds synthesized gave promising results.