Literature DB >> 10230640

4-Aryl-2-anilinopyrimidines as corticotropin-releasing hormone (CRH) antagonists.

A J Cocuzza1, F W Hobbs, C R Arnold, D R Chidester, J A Yarem, S Culp, L Fitzgerald, P J Gilligan.   

Abstract

A series of 4-aryl-2-(N-ethylanilino)pyrimidines has been synthesized as corticotropin-releasing hormone (CRH) inhibitors. The effect of substitution on each aromatic ring on receptor binding was investigated.

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Year:  1999        PMID： 10230640     DOI： 10.1016/s0960-894x(99)00132-8

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  3 in total

1.  One-pot Double Suzuki Couplings of Dichloropyrimidines.

Authors:  Samantha C Anderson; Scott T Handy
Journal:  Synthesis (Stuttg)       Date:  2010-08-01       Impact factor: 3.157

2.  Site-selective Suzuki-Miyaura coupling of heteroaryl halides - understanding the trends for pharmaceutically important classes.

Authors:  Joshua Almond-Thynne; David C Blakemore; David C Pryde; Alan C Spivey
Journal:  Chem Sci       Date:  2016-08-09       Impact factor: 9.825

3.  Antitubercular 2-Pyrazolylpyrimidinones: Structure-Activity Relationship and Mode-of-Action Studies.

Authors:  Candice Soares de Melo; Vinayak Singh; Alissa Myrick; Sandile B Simelane; Dale Taylor; Christel Brunschwig; Nina Lawrence; Dirk Schnappinger; Curtis A Engelhart; Anuradha Kumar; Tanya Parish; Qin Su; Timothy G Myers; Helena I M Boshoff; Clifton E Barry; Frederick A Sirgel; Paul D van Helden; Kirsteen I Buchanan; Tracy Bayliss; Simon R Green; Peter C Ray; Paul G Wyatt; Gregory S Basarab; Charles J Eyermann; Kelly Chibale; Sandeep R Ghorpade
Journal:  J Med Chem       Date:  2021-01-04       Impact factor: 7.446
  3 in total

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