Literature DB >> 10230619

4-Phenylthiazole derivatives inhibit IL-6 secretion in osteoblastic cells and suppress bone weight loss in ovariectomized mice.

K Yamaguchi1, M Yada, T Tsuji, Y Hatanaka, K Goda, T Kobori.   

Abstract

A series of 4-phenylthiazole derivatives were synthesized and tested their inhibitory effect on the interleukin-6 secretion stimulated by PTH in osteoblastic cells. SCRC2941-18, 2-amino-4-(4-chlorophenyl)-5-methylthiazole, was found to be the most potent inhibitor in the derivatives. Furthermore, SCRC2941-18 significantly suppressed the bone weight loss in the ovariectomized mice, an osteoporosis model.

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Year:  1999        PMID： 10230619     DOI： 10.1016/s0960-894x(99)00122-5

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  4 in total

Review 1.  Chemical genetics: ligand-based discovery of gene function.

Authors:  B R Stockwell
Journal:  Nat Rev Genet       Date:  2000-11       Impact factor: 53.242

2.  Novel potential agents for ulcerative colitis by molecular topology: suppression of IL-6 production in Caco-2 and RAW 264.7 cell lines.

Authors:  María Galvez-Llompart; María Del Carmen Recio Iglesias; Jorge Gálvez; Ramón García-Domenech
Journal:  Mol Divers       Date:  2013-06-23       Impact factor: 2.943

3.  Synthesis and Antibacterial Assessment of N-[4-(4-substituted phenyl)-1,3-thiazol-2-yl]-1,3,5-triazin-2-amine.

Authors:  P Gahtori; A Das; H Bhatt
Journal:  Indian J Pharm Sci       Date:  2009-01       Impact factor: 0.975

4.  IL-6 Contributes to the Defective Osteogenesis of Bone Marrow Stromal Cells from the Vertebral Body of the Glucocorticoid-Induced Osteoporotic Mouse.

Authors:  Xiang Li; Zong-Yu Zhou; Yuan-Yuan Zhang; Hui-Lin Yang
Journal:  PLoS One       Date:  2016-04-29       Impact factor: 3.240
  4 in total

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