Literature DB >> 10230610

Synthesis and structure-activity relationship of potent bicyclic lactam thrombin inhibitors.

B Bachand1, J DiMaio, M A Siddiqui.   

Abstract

A simple and versatile method for preparation of (D)-Phe-Pro peptidomimetic bicyclic thiazolidine lactams is presented. These bicyclic lactams have chemical diversity alpha to the lactam carbonyl and, when linked to electrophilic arginines, provide potent thrombin inhibitors.

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Year:  1999        PMID: 10230610     DOI: 10.1016/s0960-894x(99)00130-4

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  1 in total

1.  The impact of counterions in biological activity: case study of antibacterial alkylguanidino ureas.

Authors:  Claudia Ardino; Filomena Sannio; Carolina Pasero; Lorenzo Botta; Elena Dreassi; Jean-Denis Docquier; Ilaria D'Agostino
Journal:  Mol Divers       Date:  2022-08-29       Impact factor: 3.364

  1 in total

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