Literature DB >> 10230517

A new cytotoxic acyclic diterpene from Carpesium divaricatum.

O P Zee1, D K Kim, S U Choi, C O Lee, K R Lee.   

Abstract

A new acyclic diterpene (1) and a known acyclic diterpene, 12(S)-hydroxygeranylgeraniol (2) were isolated from the aerial parts of Carpesium divaricatum. The structure of 1 was determined to be (2E,10E)-1,12-dihydroxy-18-acetoxy-3,7,15-trimethylhexadeca- 2,10,14-triene (1) on the basis of spectroscopic studies. Compounds 1 and 2 exhibited cytotoxicity against cultured human tumor cell lines, A549, SK-OV-3, SK-MEL-2, XF498, and HCT15, with ED50 values ranging from 4.3-10.2 micrograms/ml and 4.1-8.3 micrograms/ml, respectively.

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Year:  1999        PMID： 10230517     DOI： 10.1007/bf02976551

Source DB:  PubMed          Journal:  Arch Pharm Res        ISSN： 0253-6269            Impact factor:   4.946


  6 in total

1.  Isolation, Structure Elucidation, and Absolute Configuration of Germacrane Isomers from Carpesium divaricatum.

Authors:  Tao Zhang; Jia-Huan Chen; Jin-Guang Si; Gang Ding; Qiu-Bo Zhang; Hong-Wu Zhang; Hong-Mei Jia; Zhong-Mei Zou
Journal:  Sci Rep       Date:  2018-08-20       Impact factor: 4.379

2.  Oxygenated Acyclic Diterpenes with Anticancer Activity from the Irish Brown Seaweed Bifurcaria bifurcata.

Authors:  Vangelis Smyrniotopoulos; Christian Merten; Daria Firsova; Howard Fearnhead; Deniz Tasdemir
Journal:  Mar Drugs       Date:  2020-11-23       Impact factor: 5.118

3.  New antiproliferative germacranolides from Carpesium divaricatum.

Authors:  Tao Zhang; Qiu-Bo Zhang; Lu Fu; Ling-Yu Li; Li-Yan Ma; Jin-Guang Si; Hong-Wu Zhang; Jian-He Wei; Shi-Shan Yu; Zhong-Mei Zou
Journal:  RSC Adv       Date:  2019-04-11       Impact factor: 4.036

4.  Eleganolone, a diterpene from the French marine alga Bifurcaria bifurcata inhibits growth of the human pathogens Trypanosoma brucei and Plasmodium falciparum.

Authors:  Jean-Baptiste Gallé; Barthélémy Attioua; Marcel Kaiser; Anne-Marie Rusig; Annelise Lobstein; Catherine Vonthron-Sénécheau
Journal:  Mar Drugs       Date:  2013-02-26       Impact factor: 5.118

5.  New Highly Oxygenated Germacranolides from Carpesium divaricatum and their Cytotoxic Activity.

Authors:  Tao Zhang; Jin-Guang Si; Qiu-Bo Zhang; Gang Ding; Zhong-Mei Zou
Journal:  Sci Rep       Date:  2016-06-06       Impact factor: 4.379

6.  Three New Highly Oxygenated Germacranolides from Carpesium Divaricatum and Their Cytotoxic Activity.

Authors:  Tao Zhang; Jin-Guang Si; Qiu-Bo Zhang; Jia-Huan Chen; Gang Ding; Hong-Wu Zhang; Hong-Mei Jia; Zhong-Mei Zou
Journal:  Molecules       Date:  2018-05-03       Impact factor: 4.411
  6 in total

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