Literature DB >> 10227647

A DLST genotype associated with reduced risk for Alzheimer's disease.

K F Sheu1, A M Brown, B S Kristal, R N Kalaria, L Lilius, L Lannfelt, J P Blass.   

Abstract

Recent studies suggest that variants of the DLST gene alter the risk of AD. DLST encodes the core subunit of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which is deficient in AD. The authors report that in 247 US white subjects, homozygosity for DLST A19,117, T19,183 was associated with a reduced risk of AD (odds ratio [OR] = 0.35, p = 0.018). The reduced risk was marked in subjects who did not carry the apolipoprotein (APOE)-4 allele (OR = 0.16, p = 0.014). Further study of DLST in AD appears warranted.

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Year:  1999        PMID： 10227647     DOI： 10.1212/wnl.52.7.1505

Source DB:  PubMed          Journal:  Neurology        ISSN： 0028-3878            Impact factor:   9.910


  9 in total

1.  Association of OGG1 and DLST promoter methylation with Alzheimer's disease in Xinjiang population.

Authors:  Wei Chen; Xiaohui Zhou; Yali Duan; Ting Zou; Guili Liu; Xiuru Ying; Qinwen Wang; Shiwei Duan
Journal:  Exp Ther Med       Date:  2018-07-26       Impact factor: 2.447

2.  Mice deficient in dihydrolipoyl succinyl transferase show increased vulnerability to mitochondrial toxins.

Authors:  Lichuan Yang; Qingli Shi; Daniel J Ho; Anatoly A Starkov; Elizabeth J Wille; Hui Xu; H L Chen; Steven Zhang; Cliona M Stack; Noel Y Calingasan; Gary E Gibson; M Flint Beal
Journal:  Neurobiol Dis       Date:  2009-08-04       Impact factor: 5.996

Review 3.  The alpha-ketoglutarate-dehydrogenase complex: a mediator between mitochondria and oxidative stress in neurodegeneration.

Authors:  Gary E Gibson; John P Blass; M Flint Beal; Victoria Bunik
Journal:  Mol Neurobiol       Date:  2005       Impact factor: 5.590

4.  NMDA receptor hypofunction induces dysfunctions of energy metabolism and semaphorin signaling in rats: a synaptic proteome study.

Authors:  Kejun Zhou; Yifeng Yang; Linghan Gao; Guang He; Weidong Li; Kefu Tang; Baohu Ji; Ming Zhang; Yang Li; Jinglei Yang; Liya Sun; Zhao Zhang; Hui Zhu; Lin He; Chunling Wan
Journal:  Schizophr Bull       Date:  2010-11-17       Impact factor: 9.306

5.  Selective loss of KGDHC-enriched neurons in Alzheimer temporal cortex: does mitochondrial variation contribute to selective vulnerability?

Authors:  L W Ko; K F Sheu; H T Thaler; W R Markesbery; J P Blass
Journal:  J Mol Neurosci       Date:  2001-12       Impact factor: 3.444

6.  Neuroglobin and Alzheimer's dementia: genetic association and gene expression changes.

Authors:  Megan Szymanski; Ruihua Wang; M Danielle Fallin; Susan S Bassett; Dimitrios Avramopoulos
Journal:  Neurobiol Aging       Date:  2008-11-17       Impact factor: 4.673

7.  Substantial linkage disequilibrium across the dihydrolipoyl succinyltransferase gene region without Alzheimer's disease association.

Authors:  Abraham M Brown; Derek Gordon; Hsinhwa Lee; Michael Caudy; Vahram Haroutunian; John P Blass
Journal:  Neurochem Res       Date:  2004-03       Impact factor: 3.996

8.  Truncated product of the bifunctional DLST gene involved in biogenesis of the respiratory chain.

Authors:  Takashi Kanamori; Kiyomi Nishimaki; Sadamitsu Asoh; Yoshitomo Ishibashi; Iichiro Takata; Tomoko Kuwabara; Kazunari Taira; Haruyasu Yamaguchi; Shiro Sugihara; Tsuneo Yamazaki; Yasuo Ihara; Kyoko Nakano; Sadayuki Matuda; Shigeo Ohta
Journal:  EMBO J       Date:  2003-06-16       Impact factor: 11.598

9.  Systematic tissue-specific functional annotation of the human genome highlights immune-related DNA elements for late-onset Alzheimer's disease.

Authors:  Qiongshi Lu; Ryan L Powles; Sarah Abdallah; Derek Ou; Qian Wang; Yiming Hu; Yisi Lu; Wei Liu; Boyang Li; Shubhabrata Mukherjee; Paul K Crane; Hongyu Zhao
Journal:  PLoS Genet       Date:  2017-07-24       Impact factor: 5.917
  9 in total

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