Cognition and neuropathology in schizophrenia.

Clinical, neuropsychological and neuropathological avenues of research have advanced in concert to increase our understanding of schizophrenia. Progress in four general areas of investigation will be reviewed: (i) fronto-temporal-limbic dysfunction; (ii) abnormal connectivity or 'miswiring'; (iii) aberrant neurodevelopment; and (iv) neurodegeneration and neural injury. The challenge for post-mortem research is to identify the molecular pathways in which abnormalities culminate in the highly diverse features of the disorder. Candidate pathways must be able to account for the developmental and deteriorative clinical profiles and the global and focal neuropsychological deficits, as well as the various patho-anatomical abnormalities that indicate aberrant cytoarchitecture and connectivity in the absence of neurodegeneration or other obvious evidence of postmaturational neural injury.