BACKGROUND: Eosinophils develop from bone marrow (BM) progenitors, and interleukin-5 (IL-5) and eotaxin may act in expansion and mobilisation of BM eosinophils in asthma. METHODS: We have examined phenotypic changes as CD34+ cells develop to the eosinophil lineage in vitro, and have evaluated BM eosinophils from asthmatic and control subjects for expression of the eotaxin receptor, CCR3. RESULTS: Acquisition of receptors for IL-5 and CCR3 was an early event in eosinophil development. There were increased CD34+ cells, and mature and immature CCR3+ eosinophils in BM from asthmatics. CONCLUSION: These data suggest that IL-5 may act early in eosinophil development, and that eotaxin has the capacity to mobilise a BM eosinophil pool in asthma.
BACKGROUND: Eosinophils develop from bone marrow (BM) progenitors, and interleukin-5 (IL-5) and eotaxin may act in expansion and mobilisation of BM eosinophils in asthma. METHODS: We have examined phenotypic changes as CD34+ cells develop to the eosinophil lineage in vitro, and have evaluated BM eosinophils from asthmatic and control subjects for expression of the eotaxin receptor, CCR3. RESULTS: Acquisition of receptors for IL-5 and CCR3 was an early event in eosinophil development. There were increased CD34+ cells, and mature and immature CCR3+ eosinophils in BM from asthmatics. CONCLUSION: These data suggest that IL-5 may act early in eosinophil development, and that eotaxin has the capacity to mobilise a BM eosinophil pool in asthma.
Authors: Terlika S Pandit; M Reza Hosseinkhani; Bit Na Kang; Nooshin S Bahaie; Xiao Na Ge; Savita P Rao; P Sriramarao Journal: Exp Lung Res Date: 2011-02-11 Impact factor: 2.459
Authors: Mark E Lauer; Durba Mukhopadhyay; Csaba Fulop; Carol A de la Motte; Alana K Majors; Vincent C Hascall Journal: J Biol Chem Date: 2008-12-16 Impact factor: 5.157
Authors: Roma Sehmi; Sandra Dorman; Adrian Baatjes; Rick Watson; Ronan Foley; Sun Ying; Douglas S Robinson; A Barry Kay; Paul M O'Byrne; Judah A Denburg Journal: Immunology Date: 2003-08 Impact factor: 7.397
Authors: S Finotto; G T De Sanctis; H A Lehr; U Herz; M Buerke; M Schipp; B Bartsch; R Atreya; E Schmitt; P R Galle; H Renz; M F Neurath Journal: J Exp Med Date: 2001-06-04 Impact factor: 14.307